In recent years, most research on typhoons in the Taiwan Strait and its adjacent waters has focused on simulating typhoon waves under the influence of wind fields. In order to study the influence of tidal level changes on typhoon waves, a numerical model was established in the Taiwan Strait based on the third-generation ocean wave model SWAN. The simulation results of the tide level during the corresponding typhoon landing time were incorporated into the model to optimize its performance. Subsequently, the wave height of the typhoon landing at the lowest tide level was compared with that at the highest tide level. This comparison serves as a reference and warning for ocean engineering, highlighting the hazards of the typhoon landing at high tide. The simulation results were verified and analyzed using the measured data of significant wave heights and wind speeds when typhoons Mekkhala (2006) and Maria (0607) approached. The results show that after optimization, the relative error of the significant wave peak is reduced. Furthermore, there has been a decrease in the maximum wind speed, bringing it closer to the measured value. These improvements signify enhanced model accuracy. The tide level has a great influence on the typhoon wave, and the tide level height at the time of the typhoon landing is positively correlated with the significant wave height of the waves generated by the typhoon. When the typhoon’s landing time coincides with the high tide level, the resulting waves are significantly higher, reaching up to 0.71 m. This has a substantial impact on the safety of marine structures, particularly breakwaters.