Difference differential amplifiers (DDA), which were built on FinFET and carbon nanotube FET (CNTFET), are frequently used for signal processing owing to their advantages of low-power dissipation and reduced device dimension. In this work, high-performance DDA was established using CNTFET model parameters as well as FinFET 7 nm and 14 nm technology. The DDA circuit used in this scenario was identically the same to the one used previously. With the use of Verilog AMS code-based Stanford model parameters applied CNTFET and 7 nm and 14 nm FinFETs, schematic capture and simulations of the DDA were carried out in the Symica environment. The mostly used measurements for assessing the performance of operational amplifiers were also adopted for DDA. The CNTFET-based difference differential amplifiers have slew rates of 10.8 V/femtosecond and 11.2 mV/femtosecond, respectively, with settling times of 0.65 femtosecond and 0.43 femtosecond, respectively. The power supply rejection ratio (PSRR) is 2.53 dB with a dynamic range of 198 mV and 6 mV for CNTFET DDA operating at 0.6 V DC. The incentives of CNTFET appropriateness for DDA designed in this study for any analogue front end were further demonstrated by using CNTFET for DDA with the achievement of open loop differential gain of 116.03 dB with BW of 4 GHz and phase margin of 270 and common mode gain of -28.65 dB with BW of 55.14 MHz and phase margin of 270.