A high prevalence of human papillomavirus DNA in recurrent nasal papillomas

Ogura, Hajime; Fukushima, Kunihiro; Watanabe, Shuichi

doi:10.1099/00222615-45-3-162

Cited by 20 publications

(12 citation statements)

References 19 publications

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“…Fifty-nine tumors were evaluated from 51 patients. These included 30 ISPs without dysplasia, 6 ISPs with dysplasia, 16 ISPs with a synchronous (n = 14) or metachronous (n = 2) SCC (i.e. SCC ex-ISP), and 7 non-keratinizing SCCs of the sinonasal tract with inverted growth.…”

Section: Resultsmentioning

confidence: 99%

“…RNA in situ hybridization for high-risk HPV E6/E7 mRNA was performed using the RNAscope HPV-HR18 Probe (Advanced Cell Diagnostics, Hayward, CA). Tumor sections were cut at five microns, pretreated with heat and protease, and hybridized with a single cocktail probe recognizing 18 high-risk HPV genotypes (16,18,26,31,33,35,39,45,51,52,53,56,58,59, 66, 68, 73, and 82). Preamplifier, amplifier and horseradish peroxidase-labeled probes were sequentially hybridized, and color was developed with diaminobenzidine.…”

Section: Hpv Rna In Situ Hybridizationmentioning

confidence: 99%

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Transcriptionally Active High-Risk Human Papillomavirus is Not a Common Etiologic Agent in the Malignant Transformation of Inverted Schneiderian Papillomas

Rooper

Bishop

Westra

2017

Head and Neck Pathol

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The role of human papillomavirus (HPV) as an etiologic and transformational agent in inverted Schneiderian papilloma (ISP) is unclear. Indeed, reported detection rates of HPV in ISPs range from 0 to 100%. The true incidence has been confounded by a tendency to conflate high- and low-risk HPV types and by the inability to discern biologically relevant from irrelevant HPV infections. The recent development of RNA in situ hybridization for high-risk HPV E6/E7 mRNA now allows the direct visualization of transcriptionally active high-risk HPV in ISP, providing an opportunity to more definitively assess its role in the development and progression of ISPs. We performed p16 immunohistochemistry and high-risk HPV RNA in situ hybridization on 30 benign ISPs, 7 ISPs with dysplasia, 16 ISPs with carcinomatous transformation, and 7 non-keratinizing squamous cell carcinomas (SCCs) with inverted growth that were unassociated with ISP. Transcriptionally active HPV was not detected in any of the 52 ISPs including those that had undergone carcinomatous transformation, but it was detected in two of seven (29%) non-keratinizing SCCs that showed inverted growth. There was a strong correlation between high-risk HPV RNA in situ hybridization and p16 immunohistochemistry (97%; p < 0.01). These results indicate that transcriptionally active high-risk HPV does not play a common role in either the development of ISP or in its transformation into carcinoma.

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Section: Resultsmentioning

confidence: 99%

Section: Hpv Rna In Situ Hybridizationmentioning

confidence: 99%

Transcriptionally Active High-Risk Human Papillomavirus is Not a Common Etiologic Agent in the Malignant Transformation of Inverted Schneiderian Papillomas

Rooper

Bishop

Westra

2017

Head and Neck Pathol

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“…In terms of aetiology there is some evidence that the presence of HPV in IP could be involved in the malignant transformation [111, 139–145] and that HPV subtyping enables a prognosis of the probability of recurrence [146]. Significant association has been identified between the presence of human papilloma virus DNA in inverted papilloma and recurrence after surgical excision [144, 147, 148]. Some authors argued against the role of HPV in the pathogenesis of exophytic papilloma while others denied its association with developing malignancy and recurrence [121, 149–151].…”

Section: Etiology and Pathogenesismentioning

confidence: 99%

Skull Base Inverted Papilloma: A Comprehensive Review

2012

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Skull base inverted papilloma (IP) is an unusual entity for many neurosurgeons. IP is renowned for its high rate of recurrence, its ability to cause local destruction, and its association with malignancy. This paper is a comprehensive review of the reports, studies, and reviews published in the current biomedical literature from 1947 to September 2010 and synthesize this information to focus on its potential invasion to the base of the skull and possible intradural extension. The objective is to familiarize the clinician with the different aspects of this unusual disease. The role of modern diagnostic tools in medical imaging in order to assess clearly the limits of the tumors and to enhance the efficiency and the safety in the choice of a surgical approach is pointed out. The treatment guidelines for IP have undergone a complex evolution that continues today. Radical excision of the tumour is technically difficult and often incomplete. Successful management of IP requires resection of the affected mucosa which could be achieved with open surgery, endoscopic, or combined approach. Radio and chemotherapy were used for certain indications. More optimally research would be a multicenter randomized trials with large size cohorts.

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“…The role of adjuvant radiotherapy in the treatment of transitional cell carcinoma has been controversial. Recurrence of a Type 1 papilloma should be managed with a repeat biopsy under frozen section control for malignant transformation with PCR analysis to look for human papilloma virus DNA 10 …”

Section: Discussionmentioning

confidence: 99%

Accidentally diagnosed transitional cell papilloma of the lacrimal sac

Dave

Mishra

Mittal

et al. 2017

Saudi Journal of Ophthalmology

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Lacrimal sac tumors are extremely rare but can be life threatening. Seventy percent of lacrimal sac tumors are of epithelial origin. Inverted transitional cell papilloma of the lacrimal sac is a rare epithelial sinonasal tumor of benign etiology with local invasion and malignant potential. These lesions may remain undiagnosed or may present with signs and symptoms of dacryocystitis or may transform to transitional cell carcinomas. Most lesions are diagnosed intra-operatively while performing a dacryocystorhinostomy. Biopsy and histopathological examination of mass lesions arising from the lacrimal sac helps in timely management of these rare tumors.

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A high prevalence of human papillomavirus DNA in recurrent nasal papillomas

Cited by 20 publications

References 19 publications

Transcriptionally Active High-Risk Human Papillomavirus is Not a Common Etiologic Agent in the Malignant Transformation of Inverted Schneiderian Papillomas

Transcriptionally Active High-Risk Human Papillomavirus is Not a Common Etiologic Agent in the Malignant Transformation of Inverted Schneiderian Papillomas

Skull Base Inverted Papilloma: A Comprehensive Review

Accidentally diagnosed transitional cell papilloma of the lacrimal sac

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