This study aims to assess the relation between late term arteriovenous fistula thrombosis and alteration in hemogram parameters before the occurrence of thrombosis in hemodialysis patients with end-stage renal failure. Materials and Methods: Data of three hemodialysis centers in our city were evaluated retrospectively. The results of hemogram values before thrombosis formation at first and third month in 14 re-operated patients between March-September 2017, owing to late term fistula thrombosis occurrence, who previously had a successful fistula access, were compared to 73 patients still having hemodailysis therapy via fistula access. Results: Statistically significant increments were measured in neutrophile to lympocyte ratio, red blood cell distribution width, mean platelet volume, platelet distribution width parameters in fistula thrombosis developed patients compared to their previous results three months before thrombosis formation and control group. No significant relation was found between thrombosis formation and other parameters in hemogram. Conclusion: Herein, it's determined that a profound examination of hemogram has a predictive value for late term fistula thrombosis in hemodialysis patients.