Since its first application in the 1950s, the laser has become an indispensable tool in scientific research and manufacturing. Laser manufacturing includes traditional methods such as cutting and engraving and emerging methods such as laser‐induced surface modification, laser‐induced materials transfer, and laser ablation synthesis. Laser manufacturing is widely applied in the fabrication of multifunctional sensing systems. Compared with other manufacturing methods such as lithography, vacuum deposition, and etching processes, laser manufacturing technology has several advantages, including maskless patterning, high precision, non‐contact processing, minimum heat affected zone, high throughput, ability to work with multiple materials, and ease of automation and integration. Here, this review aims to present a comprehensive analysis of the applications of laser manufacturing in various components of health and gas monitoring systems. Emphasis is placed on the application of laser manufacturing in various components of biosensors, including microchannels, sensing circuits, and working electrodes. Subsequently, laser manufacturing of physical and gas sensors is introduced. Meanwhile, traditional laser manufacturing methods, laser surface modification, laser‐induced material transfer, and laser ablation synthesis are introduced. Finally, the challenges and prospects of laser manufacturing in sensing systems are discussed.