A Higher Frequency of CD14+CD169+ Monocytes/Macrophages in Patients with Colorectal Cancer

Li, Chenguang; Luo, Xiaofan; Lin, Yuyang; Tang, Xiuqi; Ling, Limian; Wang, Lei; Jiang, Yanfang

doi:10.1371/journal.pone.0141817

Cited by 23 publications

(20 citation statements)

References 44 publications

(56 reference statements)

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“…In homeostatic conditions, SIGLEC1 + macrophages are mainly in the bone marrow, liver, spleen, colon, and lymph node, and they are involved in erythropoiesis and adaptive immune responses ( Chávez-Galán et al., 2015 ). Consistent with our findings, SIGLEC1 + macrophages have been identified in colorectal ( Li et al., 2015 ) and hepatocellular carcinoma ( Zhang et al., 2016 ). Infiltration of SIGLEC1 + macrophages in colorectal cancer was associated with tumor progression, but in hepatocellular carcinoma they predicted favorable patient outcomes ( Zhang et al., 2016 ), underpinning the hypothesis that TAM phenotypes/activation are organ and cancer specific.…”

Section: Discussionsupporting

confidence: 92%

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

et al. 2019

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Summary The roles of tumor-associated macrophages (TAMs) and circulating monocytes in human cancer are poorly understood. Here, we show that monocyte subpopulation distribution and transcriptomes are significantly altered by the presence of endometrial and breast cancer. Furthermore, TAMs from endometrial and breast cancers are transcriptionally distinct from monocytes and their respective tissue-resident macrophages. We identified a breast TAM signature that is highly enriched in aggressive breast cancer subtypes and associated with shorter disease-specific survival. We also identified an auto-regulatory loop between TAMs and cancer cells driven by tumor necrosis factor alpha involving SIGLEC1 and CCL8, which is self-reinforcing through the production of CSF1. Together these data provide direct evidence that monocyte and macrophage transcriptional landscapes are perturbed by cancer, reflecting patient outcomes.

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Section: Discussionsupporting

confidence: 92%

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

et al. 2019

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“…These different functions of TAMs are sometimes referred to as M1 macrophages (anti-tumorigenic) or M2 macrophages (pro-tumorigenic), although their polarization status is much more complex due to a high degree of plasticity [ 65 ]. Few studies have demonstrated that presence of TAMs and their subtype distribution in primary tumors are associated with clinical outcome of CRC patients [ 66 , 67 , 68 ]. It was found that both TAM subsets, M1 and M2, were found to be present at increased levels in primary tumors [ 68 ].…”

Section: Tumor-immune System Interactions In Crcmentioning

confidence: 99%

“…Few studies have demonstrated that presence of TAMs and their subtype distribution in primary tumors are associated with clinical outcome of CRC patients [ 66 , 67 , 68 ]. It was found that both TAM subsets, M1 and M2, were found to be present at increased levels in primary tumors [ 68 ]. Presence of M1 macrophages has been correlated with better clinical outcome [ 66 ], whereas expression of M2 macrophage markers has been correlated with worse clinical outcome in CRC [ 67 ].…”

Section: Tumor-immune System Interactions In Crcmentioning

confidence: 99%

“…The role of peripheral blood monocytes in CRC patients has not yet been studied in detail. In general, a high frequency of circulating monocytes was found in CRC patients compared to healthy donors, which was associated with advanced tumor stages [ 68 ]. Finally, no studies on the subtype distribution of NKT cells in peripheral blood of CRC patients and clinical outcome have been performed as of yet.…”

Section: Tumor-immune System Interactions In Crcmentioning

confidence: 99%

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The Immunogenicity of Colorectal Cancer in Relation to Tumor Development and Treatment

Vries

Swets

Vahrmeijer

et al. 2016

IJMS

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Although most cancer types have been viewed as immunologically silent until recently, it has become increasingly clear that the immune system plays key roles in the course of tumor development. Remarkable progress towards understanding cancer immunogenicity and tumor-immune system interactions has revealed important implications for the design of novel immune-based therapies. Natural immune responses, but also therapeutic interventions, can modulate the tumor phenotype due to selective outgrowth of resistant subtypes. This is the result of heterogeneity of tumors, with genetic instability as a driving force, and obviously changes the immunogenicity of tumors. In this review, we discuss the immunogenicity of colorectal cancer (CRC) in relation to tumor development and treatment. As most tumors, CRC activates the immune system in various ways, and is also capable of escaping recognition and elimination by the immune system. Tumor-immune system interactions underlie the balance between immune control and immune escape, and may differ in primary tumors, in the circulation, and in liver metastases of CRC. Since CRC immunogenicity varies between tumors and individuals, novel immune-based therapeutic strategies should not only anticipate the molecular profile, but also the immunological profile of a specific tumor.

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“…Recently, several studies suggested that M2-like TAMs in breast cancer tissue could migrate into peripheral blood to become circulating M2-like monocytes and facilitate breast tumor metastasis 15 - 17 . Furthermore, circulating M2-like monocytes are elevated in some cancers, such as lung cancer 18 , colorectal cancer 19 , and classical Hodgkin Lymphoma 20 . Therefore, circulating M2-like monocytes may serve as a new tumor biomarker for breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Combination of plasma HA and circulating M2-like monocytes may serve as a diagnostic marker for breast cancer

et al. 2017

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Background: Breast cancer (BC)-derived hyaluronan (HA) can induce the formation of M2-like tumor-associated macrophages (TAMs) in tumor context. However, little is known about the correlation between circulating M2-like monocytes and plasma HA in BC patients. This study focused on evaluating the relationship between circulating M2-like monocytes and plasma HA, and further appraised the diagnostic value of them in BC.Methods: The expression of M2-like TAMs and HA was determined in pathological tissues by immunohistochemistry. Flow cytometry was used to detect the levels of circulating CD14+CD204+ M2-like monocytes in 81 BC patients, 45 patients with breast benign diseases, and 46 healthy subjects. The levels of HA, CEA, and CA15-3 were measured in plasma samples using chemiluminescence method.Results: M2-like TAMs and HA expressions were elevated in BC tissues compared with benign tissues. In correspondence, the frequency of circulating CD14+CD204+ M2-like monocytes and the plasma HA levels were significantly higher in patients with BC than those in control groups. Importantly, there was a positive correlation between circulating M2-like monocytes and the plasma HA (Spearman r = 0.404, p < 0.001). Area under receiver operating characteristic curve (ROC) for the combination of circulating M2-like monocytes and HA was 0.899 (95% CI: 0.853-0.946), which was higher than the panel of CEA and CA15-3.Conclusions: The frequency of circulating CD14+CD204+ M2-like monocytes was positively correlated to plasma HA levels. The combination of circulating CD14+CD204+ M2-like monocytes and plasma HA could provide considerable diagnostic value in BC.

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A Higher Frequency of CD14+CD169+ Monocytes/Macrophages in Patients with Colorectal Cancer

Cited by 23 publications

References 44 publications

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

The Immunogenicity of Colorectal Cancer in Relation to Tumor Development and Treatment

Combination of plasma HA and circulating M2-like monocytes may serve as a diagnostic marker for breast cancer

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