A Higher Frequency of CD4<sup>+</sup>CXCR5<sup>+</sup>T Follicular Helper Cells in Adult Patients with Minimal Change Disease

Zhang, Nan; Zhao, Pingwei; Shrestha, Ashis; Zhang, Li; Qu, Zhen; Liu, Mingyuan; Zhang, Songling; Jiang, Yanfang

doi:10.1155/2014/836157

Cited by 7 publications

(5 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The serum levels of interleukin-17A, interferon-g, interleukin-2, interleukin-10, interleukin-4, and interleukin-21 are significantly higher in patients with MCD than in healthy controls, and this may translate into foot process fusion and consequent nephrotic syn-haematologica | 2015; 100 (9) © F e r r a t a S t o r t i F o u n d a t i o n drome. 41,42 A similar mechanism has been advocated for MCD complicating B-cell neoplasias, including CLL and other non-Hodgkin lymphomas, in which T-cell dysfunction is a common finding. 23,43,44 It should be noted that all cases of MCD in our series presented with the nephrotic syndrome.…”

Section: © F E R R a T A S T O R T I F O U N D A T I O Nmentioning

confidence: 98%

See 1 more Smart Citation

Renal complications in chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis: the Mayo Clinic experience

et al. 2015

View full text Add to dashboard Cite

© F e r r a t a S t o r t i F o u n d a t i o ntent interstitial lymphocytic infiltration was observed. Standard processing of kidney biopsies evaluated at the Mayo Clinic included light microscopy, immunofluorescence, and electron microscopy. For light microscopy, biopsy specimens were stained with hematoxylin-eosin, periodic acid Schiff, Masson trichrome, and Jones methenamine silver. For immunofluorescence, 3-micron cryostat sections were stained with polyclonal fluorescein isothiocyanate-conjugated antibodies to IgG, IgM, IgA, C3, C1q, kappa and lambda light chains, fibrinogen, and albumin (Dako), as per routine clinical testing. Electron microscopy was performed as per clinical routine.Immunohistochemical stains for CD3, CD5, CD20, and CD23 were done in cases of interstitial lymphocytic infiltration (and for PAX5 and CD19 in selected cases) to help assess CLL/SLL involvement. Renal biopsy findings were further classified according to a potential causal relationship with CLL. Cases of membranoproliferative glomerulonephritis (MPGN), CLL infiltrate as primary etiology, minimal change disease (MCD), acute interstitial nephritis, amyloidosis, light chain cast nephropathy, membranous glomerulonephritis, and unclassified mesangial proliferative glomerulonephritis were considered directly related to CLL. Cases secondary to CLL-associated conditions, such as infections, autoimmune disease, and other cancers, or CLL treatment were considered potentially indirectly related to CLL. Cases secondary to non-CLL associated comorbidities or non-CLL treatment, such as diabetes, hypertension or obesity, were considered unrelated to CLL. Statistical analysisDescriptive statistics of baseline characteristics were calculated. The Mann-Whitney test was used for comparisons of medians. Overall survival was defined as time from diagnosis to death or last follow up. Survival curves were calculated using the Kaplan-Meier method, and comparisons were made using the log-rank test. All P-values were two-sided and considered statistically significant if ≤0.05. Statistical analyses were completed using SPSS 21. Results Baseline characteristicsBetween January 1 st , 1995 and June 30 th , 2014, 4,024 patients with CLL, SLL or MBL were followed at our institution. Of these patients, 49 (1.2%) had an ultrasound-guided kidney biopsy during follow-up to evaluate renal failure and/or nephrotic syndrome. Of these biopsies, 10% were performed before 2005, 49% between 2005 and 2010, and 41% after 2010. The indication for renal biopsy was renal insufficiency (without evidence of post-renal compression or tumor lysis) in 34 patients (69%; median creatinine 3.2 mg/dL, range 1.7-15) and nephrotic syndrome in 15 (31%; median proteinuria 11.3 g/24 hours, range 4-54.9). The pertinent baseline characteristics of these 49 patients at the time of CLL diagnosis are shown in Table 1.Kidney biopsy results are shown in Table 2. The distribution of renal pathology based on the indication for biopsy is shown in Figure 1. Of interest, among the five patie...

show abstract

Section: © F E R R a T A S T O R T I F O U N D A T I O Nmentioning

confidence: 98%

“…41,42 A similar mechanism has been advocated for MCD complicating B-cell neoplasias, including CLL and other non-Hodgkin lymphomas, in which T-cell dysfunction is a common finding. 23,43,44 It should be noted that all cases of MCD in our series presented with the nephrotic syndrome.…”

mentioning

confidence: 98%

Renal complications in chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis: the Mayo Clinic experience

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Data from human studies on cTfh cells in RA patients clearly corroborate mouse data on aberrant Tfh numbers ( Table 1 ). Several studies have reported an increase in cTfh cells in RA patients, accompanied by elevated IL-21 levels in some cases [ 65 , 66 , 67 , 68 , 69 , 70 , 71 ]. However, it is important to note that while there are increase Tfh numbers both in murine and human GCs, the underlying mechanism responsible for their expansion remains to be fully unraveled.…”

Section: Germinal Centers In Rheumatoid Arthritismentioning

confidence: 99%

“…Arroyo-Villa et al [65] RA patients with active disease have a higher frequency of Tfh cells and a higher Tfh/Tfr ratio resulting from lower Tfr frequencies Zhang et al [66] Increased frequencies of Tfh cells and IL-21 in RA patients which correlates positively with DAS28 Wang et al [67], Zhou et al [69] Increased frequencies of Tfh cells in newly diagnosed RA patients correlating with activated B cells and DAS28 Niu et al [68] Elevated frequencies of Tfh cells, IL-21 and PD-1 in RA patients with active disease Nakayamada et al [70] Higher proportions of Tfh cells in RA patients with active disease and, treatment with Abatacept reduces Tfh cell levels. Su et al [71] Elevated frequencies of Tfh cells in RA patients compared to HCs…”

Section: Tfh Cells In Ra Findingsmentioning

confidence: 99%

The Germinal Center Milieu in Rheumatoid Arthritis: The Immunological Drummer or Dancer?

Anang

Balzaretti

Kampen

et al. 2021

IJMS

View full text Add to dashboard Cite

Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation, affecting approximately 1% of the general population. To alleviate symptoms and ameliorate joint damage, chronic use of immunosuppressives is needed. However, these treatments are only partially effective and may lead to unwanted side effects. Therefore, a more profound understanding of the pathophysiology might lead to more effective therapies, or better still, a cure. The presence of autoantibodies in RA indicates that B cells might have a pivotal role in the disease. This concept is further supported by the fact that a diverse antibody response to various arthritis-related epitopes is associated with arthritis development. In this context, attention has focused in recent years on the role of Germinal Centers (GCs) in RA. Since GCs act as the main anatomic location of somatic hypermutations, and, thus, contributing to the diversity and specificity of (auto) antibodies, it has been speculated that defects in germinal center reactions might be crucial in the initiation and maintenance of auto-immune events. In this paper, we discuss current evidence that various processes within GCs can result in the aberrant production of B cells that possess autoreactive properties and might result in the production of RA related autoantibodies. Secondly, we discuss various (pre-)clinical studies that have targeted various GC processes as novel therapies for RA treatment.

show abstract

“…Moreover, they also suppress intestinal inflammation in murine models [ 23 , 24 ]. In previous studies, we have proved that activated B and T follicular helper (TFH) cells can contribute to the pathogenesis of minimal change disease (MCD) and hepatitis B virus-associated membranous nephropathy (HBV-MN) [ 25 , 26 ]. In addition, we have found that several CD19 + B cell subtypes and IL-10 + Bregs are differentially expressed in IgA-nephritis patients [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

A Lower Proportion of Regulatory B Cells in Patients with Henoch–Schoenlein Purpura Nephritis

Tai

et al. 2016

PLoS ONE

Self Cite

View full text Add to dashboard Cite

BackgroundHenoch—Schoenlein purpura is the one of most common types of systemic vasculitis that involves impaired renal function and Henoch-Schoenlein purpura nephritis (HSPN). The diagnosis of this condition is largely based on immunohistologic detection of immunoglobulin A1-containing immune complex in the glomerular deposits of mesangium. Despite clinical advances, the etiopathogenesis of HSPN is still largely unknown.MethodsIn this study, we enrolled 25 newly diagnosed HSPN patients and 14 healthy controls. Then, fractions of B cell subtypes were determined in venous blood using flow cytometry. The serum interleukin (IL)-10 concentration was determined by enzyme-linked immunosorbent assay.ResultsCompared to those in healthy controls, the numbers of CD38+CD19+, CD86+CD19+, CD38+CD86+CD19+, and CD95+CD19+ B cells per microliter of blood were significantly higher in HSPN patients. In contrast, the numbers of CD5+CD19+, IL-10+CD19+, CD5+CD1d+CD19+, and IL-10+CD5+CD1d+CD19+ B cells per microliter of blood and the serum IL-10 concentration were significantly lower in HSPN patients. Following treatment, the numbers of CD38+CD19+ and CD86+CD19+ B cells per microliter of blood were significantly reduced in HSPN patients. However, the numbers of CD5+CD1d+CD19+, CD5+CD1d+IL-10+CD19+, and IL-10+CD19+ B cells per microliter of blood and the serum IL-10 concentration were significantly increased in HSPN patients following treatment. The estimated glomerular filtration rate (eGFR) was negatively correlated with the number of CD38+CD19+ B cells but positively correlated with the numbers of IL-10+CD19+, CD1d+CD5+CD19+, and IL-10+CD1d+CD5+CD19+B cells per microliter of blood and the serum IL-10 concentration. The 24-h urinary protein concentration was positively correlated with the number of CD38+CD19+B cells but negatively correlated with the numbers of IL-10+CD19+, CD1d+CD5+CD19+, and IL-10+CD1d+CD5+CD19+B cells per microliter of blood and the serum IL-10 concentration.ConclusionOur results suggest that CD38+CD19+ and CD1d+CD5+CD19+ B cells (Bregs) contribute to the pathogenesis of HSPN.

show abstract

A Higher Frequency of CD4⁺CXCR5⁺T Follicular Helper Cells in Adult Patients with Minimal Change Disease

Cited by 7 publications

References 49 publications

Renal complications in chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis: the Mayo Clinic experience

Renal complications in chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis: the Mayo Clinic experience

The Germinal Center Milieu in Rheumatoid Arthritis: The Immunological Drummer or Dancer?

A Lower Proportion of Regulatory B Cells in Patients with Henoch–Schoenlein Purpura Nephritis

Contact Info

Product

Resources

About

A Higher Frequency of CD4+CXCR5+T Follicular Helper Cells in Adult Patients with Minimal Change Disease

Cited by 7 publications

References 49 publications

Renal complications in chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis: the Mayo Clinic experience

Renal complications in chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis: the Mayo Clinic experience

The Germinal Center Milieu in Rheumatoid Arthritis: The Immunological Drummer or Dancer?

A Lower Proportion of Regulatory B Cells in Patients with Henoch–Schoenlein Purpura Nephritis

Contact Info

Product

Resources

About

A Higher Frequency of CD4⁺CXCR5⁺T Follicular Helper Cells in Adult Patients with Minimal Change Disease