A highly efficient, low-toxic, wide-spectrum antibacterial coating designed for 3D printed implants with tailorable release properties

Xue, Chaowen; Song, Xiangwei; Liu, Mingzhuo; Ai, Fanrong; Liu, Miaoxing; Shang, Qian-Nan; Shi, Xiaotong; Li, Fengshun; He, Xiaoyi; Xie, Lin‐Hua; Chen, Tingtao; Xin, Hong‐Bo; Wang, Xiaolei

doi:10.1039/c7tb00478h

Cited by 13 publications

(9 citation statements)

References 54 publications

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“…Previous work and related literature further confirmed this conclusion. 16,31,32 Collectively, the modification of carbon membrane could make the Ag nanoparticles more biocompatible and stable. 31 More importantly, the antibacterial properties of these nanocomposites were also improved compared to the similar sized bare Ag nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

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NaCl: for the safer in vivo use of antibacterial silver based nanoparticles

Liu¹,

Zhang²,

Song³

et al. 2018

IJN

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Background As antibiotics progressively cease to be effective, silver based nanoparticles (SBNs), with broad antibacterial spectrum, might be the last line of defense against malicious bacteria. Unfortunately, there are still no proper SBNs-based strategies for in vivo antibacterial therapies. In this article, new carbon membrane packaged Ag nanoparticles (Ag-C) were synthesized. We assessed the effect of Ag-C with NaCl on size, cytotoxicity, antibacterial properties, metabolism and sepsis models. Methods The size of Ag-C with NaCl was accessed with UV-vis, TEM and SEM. Staphylococcus aureus , Escherichia coli and Pseudomonas aeruginosa were used to illustrate the antibacterial properties of SBNs affected by NaCl. L929 and 3T3 cell lines were cultured in vitro; CCK-8 assay was used to test cytotoxicity. Then, we explored the metabolism of Ag-C with NaCl in vivo. Finally, the effect of Ag-C with 4× NaCl on sepsis was observed. Results NaCl could regulate the size of Ag-C. Ag-C exhibited superior antibacterial properties compared to similar sized pure Ag nanoparticles. Furthermore, the addition of NaCl could not only reduce the cytotoxicity of Ag-C, but could also continue to discharge Ag-C from major organs. Based on these factors, this method was used to treat a sepsis model (induced via cecal ligation and puncture), and it achieved satisfactory survival results. Conclusion This discovery, though still in its infancy, could significantly improve the safety and feasibility of SBNs and could potentially play an important role in modern in vivo antibacterial applications. Thus, a new method to combating the growing threat from drug-resistant bacteria could be possible. NaCl is the key to excretion of SBNs after in vivo antibacterial use.

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Section: Discussionmentioning

confidence: 99%

“…[14][15][16][17] In theory, SBNs might also have an inhibitory effect on pathogens in vivo, including some drug-resistant strains. If the safe use of SBNs in the body was guaranteed, it might be able to replace some existing antibiotics.…”

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confidence: 99%

NaCl: for the safer in vivo use of antibacterial silver based nanoparticles

Liu¹,

Zhang²,

Song³

et al. 2018

IJN

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“…They have been used to manufacture highly customized implant systems, combining 3D printing technology and surface nano‐modification. [ 145 ] By changing the content of silver nanoparticles, the proportion of the polymer and the 3D‐printed form, the loading and release rate of silver nanoparticles could be controlled according to the requirements of a specific disease, in agreement with the development of a personalized treatment.…”

Section: D Printing and Nanotechnology Alliancementioning

confidence: 99%

“…In vitro and in vivo tests demonstrated the effectiveness of this approach: The surface film slowly dissolved at 37 °C (body temperature) and the silver nanoparticles were gradually released to kill the bacteria (methicillin‐resistant S. aureus [MRSA]), preventing the infection of the injured area. [ 145 ]…”

Section: D Printing and Nanotechnology Alliancementioning

confidence: 99%

3D Printing and Nanotechnology: A Multiscale Alliance in Personalized Medicine

Santos

Oliveira

et al. 2021

Adv Funct Materials

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3D printing and nanotechnology have been two important tools in the development of therapeutic approaches for personalized medicine. More recently, their alliance has been improved in an effort to build innovative, versatile, multifunctional, and/or smart medical and pharmaceutical products. Therefore, an extensive review about scientific studies that ally 3D printing and nanomaterials in the development of new approaches for pharmaceutical and medical applications for the treatment and prevention of diseases is presented here. The articles are classified into five categories according to their main application: Cell growth and tissue engineering, antimicrobial, drug delivery, stimulus‐response, and theranostics. Semisolid extrusion, inorganic nanoparticles, and cell growth and tissue engineering are the most reported 3D printing technique, type of nanomaterial, and application, respectively. The increase in papers dedicated to these areas is also notable, especially in the 2019 and 2020, when semisolid extrusion became the most used technique, overcoming fused deposition modelling. In fact, this review highlights that the possibility of an alliance between 3D printing and nanotechnology for the production of multiscale materials is undoubtedly a great opportunity for knowledge and innovation in the pharmaceutical and medical area.

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“…The release was reported to be fastest at lower pH and for smaller NPs. Xue et al (2017) embedded Ag NPs in polyvinyl alcohol-polyacrylic acid polymer coated on 3D-printed implants and Ag NP release was estimated by measuring absorption. The authors stated that generally the bactericidal effect of Ag is mediated by Ag ions; presumably, the coating they developed would also release Ag ions, although this possibility was not explored.…”

Section: Introductionmentioning

confidence: 99%

Potential ecotoxicological effects of antimicrobial surface coatings: a literature survey backed up by analysis of market reports

Rosenberg

Ilić

Juganson

et al. 2019

PeerJ

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This review was initiated by the COST action CA15114 AMICI “Anti-Microbial Coating Innovations to prevent infectious diseases,” where one important aspect is to analyze ecotoxicological impacts of antimicrobial coatings (AMCs) to ensure their sustainable use. Scopus database was used to collect scientific literature on the types and uses of AMCs, while market reports were used to collect data on production volumes. Special attention was paid on data obtained for the release of the most prevalent ingredients of AMCs into the aqueous phase that was used as the proxy for their possible ecotoxicological effects. Based on the critical analysis of 2,720 papers, it can be concluded that silver-based AMCs are by far the most studied and used coatings followed by those based on titanium, copper, zinc, chitosan and quaternary ammonium compounds. The literature analysis pointed to biomedicine, followed by marine industry, construction industry (paints), food industry and textiles as the main fields of application of AMCs. The published data on ecotoxicological effects of AMCs was scarce, and also only a small number of the papers provided information on release of antimicrobial ingredients from AMCs. The available release data allowed to conclude that silver, copper and zinc are often released in substantial amounts (up to 100%) from the coatings to the aqueous environment. Chitosan and titanium were mostly not used as active released ingredients in AMCs, but rather as carriers for other release-based antimicrobial ingredients (e.g., conventional antibiotics). While minimizing the prevalence of healthcare-associated infections appeared to be the most prosperous field of AMCs application, the release of environmentally hazardous ingredients of AMCs into hospital wastewaters and thus, also the environmental risks associated with AMCs, comprise currently only a fraction of the release and risks of traditional disinfectants. However, being proactive, while the use of antimicrobial/antifouling coatings could currently pose ecotoxicological effects mainly in marine applications, the broad use of AMCs in other applications like medicine, food packaging and textiles should be postponed until reaching evidences on the (i) profound efficiency of these materials in controlling the spread of pathogenic microbes and (ii) safety of AMCs for the human and ecosystems.

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A highly efficient, low-toxic, wide-spectrum antibacterial coating designed for 3D printed implants with tailorable release properties

Abstract: A broad spectrum antibacterial coatings with tailorable release properties were developed for 3D printed implants.

Cited by 13 publications

References 54 publications

NaCl: for the safer in vivo use of antibacterial silver based nanoparticles

NaCl: for the safer in vivo use of antibacterial silver based nanoparticles

3D Printing and Nanotechnology: A Multiscale Alliance in Personalized Medicine

Potential ecotoxicological effects of antimicrobial surface coatings: a literature survey backed up by analysis of market reports

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