A highly selective and sensitive “off-on” fluorescent probe for the detection of nerve agent mimic DCNP in solution and vapor phase

Synthesis of a trinuclear zinc(ii) cluster composed of [4.4.3.01,5]tridecane cages: a rapid detection and degradation probe for the chemical warfare agent simulant diethyl cyanophosphonate in protein-rich food products

“…The current probe is found to be better than previously reported turn off probes in terms of LOD and selectivity. Moreover, it shows a dual role in the detection and degradation of DCNP whereas the degradation is not reported in the previous reports 18,23,46,47 (summarized in the ESI Table S4†).…”

“…10 Amongst several methods reported for organophosphate detection, [11][12][13][14][15][16] spectrofluorometric analysis has attracted increasing attention due to its low cost, high sensitivity, simplicity and real-time detection. 17 A few spectrofluorometric probes have been developed for the detection of DCNP using the hemicyanine dye, 18 carbazole-pyrrole Schiff base, 19 borondipyrromethene Schiff base, 20 imidazopyridine-pyrene, 21 4-aminophthalimide 22 and in situ generated Schiff base-Zn 2+ conjugates. 23 These probes interact with OPs through the -OH site just like acetylcholinesterase and are non-selective because most of the OPs tend to bind via this mode.…”

Fluorescent probes for the detection of chemical warfare agents

“…Xu et al reported an OFF–ON fluorescent probe, HCY ( 137 ), for the detection of DECP in DMF–H 2 O. 149 When in contact with DECP, the fluorescence emission of 137 ( λ em = 435 nm) increased 178-fold. This result was ascribed to the nucleophilic addition of CN − to HCY .…”

Advances in Noble-Metal Nanoparticle-Based Fluorescence Detection of Organophosphorus Chemical Warfare Agents

“…This technology is less precise than spectrometric methods, but it is affordable, easy to use, and portable . Fluorescence-based techniques are widely used in trace detection, biological imaging, diagnostics, optoelectronics, and forensics because they represent simple and ubiquitous analytical approaches. , With its fast response time, low false alarm rate, low cost, and realistic temperature range, it provides “naked eye” detection with contrast and versatility. It is portable and allows point-of-care testing (POCT) to perform real-time monitoring of the analyte of interest .…”