A highly selective fluorescent chemosensor for NADH based on calix[4]arene dimer

Highly functionalized calix[4]arenesviamulticomponent reactions: synthesis and recognition properties

“…7). 16 Two new calix [4]arene based receptors 11a and 11b were introduced for saccharide recognition in aqueous solution by Mirza-Aghayan et al For this purpose, the mono-aldehyde calix [4]arene 11 as a carbonyl compound was used in two different MCRs (Schemes 18 and 19). In the rst one, novel 1,4dihydropyridine-calix [4]arene 11a was achieved through a pseudo 3-CR of compound 11 with two equivalent of methyl 3aminocrotonate in the presence of TMSCl.…”

“…[8][9][10] The possibility of divers functionalization at lower and/or upper rim as well as unique conformational properties have made calix [4]arenes versatile templates to design outstanding supramolecular structures with several binding sites in an array complementary to a potential guest. [11][12][13] The molecular hosts based on calix [4]arene scaffold have been employed in many applications, 14,15 such as chemical sensing, [16][17][18] drug and gen delivery, [19][20][21][22] enzyme mimicking, 23,24 stationary phase, [25][26][27] extractants, 28,29 enzyme inhibitors, [30][31][32] catalysts [33][34][35] and etc.…”

Systematic Study of the Effect of Lower-Rim Methylation on Small Guest Binding within the Host Cavity of Calix[4]arene

“…It was realized that this allowed guests to diffuse throughout the storage medium with obvious benefits in terms of storage capacity, throughput and subsequent controlled release 24−28 of the gas. Following these advances, calixarenes have found application in areas such as storage of toxic and unstable compounds, 29 gas phase optical detectors 30 and the environmental detection of silver ions, 31 fluoride ions, 32 arsenic, 33 NADH, 34 and dopamine. 35 Recently, our own investigations found that the use of polymetallic clusters had an impact on binding strengths of guests at the upper-rim, 18,36 and in this work, we aim to continue our investigations into finely tuned control of guest binding within C [4].…”

“…It was realized that this allowed guests to diffuse throughout the storage medium with obvious benefits in terms of storage capacity, throughput and subsequent controlled release − of the gas. Following these advances, calixarenes have found application in areas such as storage of toxic and unstable compounds, gas phase optical detectors and the environmental detection of silver ions, fluoride ions, arsenic, NADH, and dopamine …”

Dicyanoisophorone-Based Near-Infrared-Emission Fluorescent Probe for Detecting NAD(P)H in Living Cells and in Vivo

“…Inspired by the enzyme-catalyzed reactions, Chang’s group has designed a boronic acid containing fluorescent NADH probe based on resazurin, in which boronic acid was selected as the binding site of NADH to accelerate the reduction process of weakly fluorescent resazurin to strongly fluorescent resorufin . In addition, fluorescent probes based on coumarin, fluorescein, cyanine, calix[4]­arene dimers, and others , have also been reported. However, most of these possess short emission wavelengths that hinder their application in living systems (Table S1).…”