Highly functionalized calix[4]arenesviamulticomponent reactions: synthesis and recognition properties

Abstract

Multicomponent reactions (MCRs) include several aspects of green chemistry principles, so it is obvious that chemists in different areas are increasingly interested in providing their product by multicomponent approaches.

Synthesis of a new chitosan- p-tert -butylcalix[4]arene polymer as adsorbent for toxic mercury ion

“…The calixarene structure includes a polar (lower) rim, a non-polar (upper) rim and a hydrophobic cavity. The phenolic hydroxyls in the polar rim and the aromatic moiety in the non-polar rim can be easily functionalized by the conventional synthetic transformations to achieve desirable supramolecular systems [40]. As a result of flexible conformation and ease of structural and functional modifications, the internal cavity of calixarenes could be a promising versatile host for different chemical species like ions and organic molecules [41][42][43].…”

A Green Catalyst Fe(OTs)3/SiO2 for theSynthesis of 4‐Pyrrolo‐12‐oxoquinazolines

“…[18] The multicomponent strategy is considered as the most efficient way to accomplish the synthesis of structurally diversified, drug like molecules involving the generation of multiple bonds in one-pot operation, without isolating the intermediates and without altering the reaction conditions. [19,20,21,22] The fast, automated, time efficient and highthroughput generation of the compounds brings the multicomponent reactions (MCRs) as powerful tools in the modern drug discovery process. [23,24] Over the past few decades, as a result of immense environmental concerns, more attention has been focused on the design of new MCRs with green and ecofriendly conditions, particularly to avoid the use of toxic and volatile organic solvents.…”

“…The multicomponent strategy is considered as the most efficient way to accomplish the synthesis of structurally diversified, drug like molecules involving the generation of multiple bonds in one‐pot operation, without isolating the intermediates and without altering the reaction conditions [19,20,21,22] . The fast, automated, time efficient and high‐throughput generation of the compounds brings the multicomponent reactions (MCRs) as powerful tools in the modern drug discovery process [23,24] .…”