A highly sensitive assay for ritodrine in human serum by hydrophilic interaction chromatography-tandem mass spectrometry

Validation of bioanalytical LC–MS/MS assays: Evaluation of matrix effects

“…Proper investigation of matrix effects includes, in addition to the absolute matrix effect, the study of matrices from different sources [27,29,[69][70][71][72][73][74][75][76][77][78][79][80].…”

Quantification of peramivir (a novel anti-influenza drug) in human plasma by hydrophilic interaction chromatography/tandem mass spectrometry

“…The possible separation mechanism and other aspects of HILIC have been recently reviewed by Hemström and Irgum [16]. It has been proved to be a valuable tool for the MS analysis of polar compounds in biological samples [17][18][19][20][21][22][23][24][25]. HILIC can result in advantages compared to reversed-phase chromatography as follows: MS sensitivity improvement due to higher organic content in the mobile phase, higher flow rates, and less matrix effect [26].…”

Emerging Analytical Separation Techniques with High Throughput Potential for Pharmaceutical Analysis, Part II: Novel Chromatographic Modes

“…HILIC methods were developed to be applied during drug monitoring, pharmacokinetic and drug-drug interaction studies [6][7][8][9][10][11][12][13][14][15][16][17]. Many pharmaceutical compounds and/or their metabolites were determined in human plasma, e.g.…”