Emerging Analytical Separation Techniques with High Throughput Potential for Pharmaceutical Analysis, Part II: Novel Chromatographic Modes

Dejaegher, Bieke; Pieters, Sigrid; Heyden, Yvan Vander

doi:10.2174/138620710791516030

Cited by 9 publications

(2 citation statements)

References 43 publications

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“…They were initially marketed under the name of HALO and similar technology was developed by Sigma-Aldrich under the name of Ascentis and Phenomenex under the name of Kinetex ® (117). For its part HILIC ® is a special case of normal phase chromatography, in which the stationary phase is less polar than the mobile phase, facilitating the analysis of polar molecules that elute with the dead volume in conventional HPLC systems (118). In general, HILIC ® mechanism is based on a type of liquid-liquid partition chromatography (LLPC) (119)(120).…”

Section: Qualitative and Quantitative Analysis Of Pharmaceutical Cont...mentioning

confidence: 99%

Pharmaceutical Products in the Environment: Sources, Effects and Risks

NARVAEZ¹,

JIMÉNEZ²

2012

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Pharmaceuticals and personal care products have become an environmental problem in recent years. Their physicochemical properties and persistence in the environment have allowed the distribution of degradates and parent compounds in water, soil, air and food. The widespread use of pharmaceuticals and personal care products in hospitals, domestic residences, agricultural and industrial facilities has increased their discharge into the water bodies, and its toxicity has started to manifest in different biological components of ecosystems. The development of methods for sample treatment and instrumental analysis techniques has enabled the separation, identification and quantification of active ingredients and degradates with higher environmental impact, at concentrations of parts per billion or even parts per trillion. In addition, in vitro and in vivo assays have demonstrated their ecotoxicity in water, driving them to the classification of emerging organic pollutants, whose waste is indeterminate. Although their adverse effects are still unknown, they could have strong implications for global public health. This review presents the dynamics and the development of research over the past ten years about the presence of non-steroidal anti-inflammatory analgesics, antihypertensives, antibiotics and other drugs in water bodies. Similarly, it described the impact of pharmaceutical activity, hospital services and domestic effluents on water quality.

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Section: Qualitative and Quantitative Analysis Of Pharmaceutical Cont...mentioning

confidence: 99%

Pharmaceutical Products in the Environment: Sources, Effects and Risks

NARVAEZ¹,

JIMÉNEZ²

2012

Vitae

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“…This technique is considered as a new focal point in the eld of liquid chromatographic studies. [16][17][18] Thus, in the present study, a highly rugged, selective and rapid UPLC method has been developed and fully validated as per the USFDA guidelines for measurement of kaempferide in rat plasma using diazepam as the internal standard (IS). The method offered a small turnaround time for analysis and high sensitivity for the analyte and utilized only 100 mL rat plasma for sample processing using a simple one-step liquid-liquid extraction by ethyl acetate.…”

Section: Introductionmentioning

confidence: 99%