A highly sensitive method for diagnosis of secondary amyloidosis by labial salivary gland biopsy

Delgado, W.; Mosqueda, A

doi:10.1111/j.1600-0714.1989.tb00403.x

Cited by 60 publications

(37 citation statements)

References 19 publications

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“…In a recent report, Delgado and Mosqueda (4) suggested that labial salivary gland (LSG) biopsy was a valuable method for detecting amyloid in patients with type AA amyloidosis. We studied prospectively the value of a combination of Congo red staining and immunohistologic staining, using an antibody directed against serum amyloid P (SAP) component, in detecting amyloid deposits in LSG tissues.…”

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confidence: 99%

Labial salivary gland biopsy is a reliable test for the diagnosis of primary and secondary amyloidosis. a prospective clinical and immunohistologic study in 59 patients

Hachulla

Janin

Flipo

et al. 1993

Arthritis & Rheumatism

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Objective. Reports of the detection of amyloidosis by labial salivary gland (LSG) biopsy have been mostly anecdotal. The aim of this study was to assess the value of this method in the diagnosis of amyloidosis.Methods. LSG biopsy tissues were studied with a combination method using Congo red stain and immunohistologic characterization using an antibody directed against the serum amyloid P (SAP) component. Electron microscopy was performed in all cases. In a prospective study, we evaluated 30 patients with biopsy‐proven AA or AL amyloidosis. We compared these patients with a control group of 29 age‐matched patients without clinical or biologic evidence of amyloid disease (14 had rheumatoid arthritis and 15 had plasma cell dyscrasia).Results. In 26 of the 30 patients with known systemic amyloidosis, amyloid deposits were identified on LSG biopsy (sensitivity of 86%). In 1 of the remaining patients, amyloid deposits were identified on LSG biopsy and systemic amyloidosis was confirmed by abdominal fat biopsy and 123I‐labeled SAP scintigraphy.Conclusion. This study emphasizes the high sensitivity of LSG biopsy in the diagnosis of amyloidosis, even in the absence of oral symptoms.

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confidence: 99%

Labial salivary gland biopsy is a reliable test for the diagnosis of primary and secondary amyloidosis. a prospective clinical and immunohistologic study in 59 patients

Hachulla

Janin

Flipo

et al. 1993

Arthritis & Rheumatism

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“…Sampling of gingiva [20,61] and accessory salivary glands [19,20,26,27] do not require special endoscopic equipment, while biopsies from the stomach (Fig. 1), duodenum, colon and rectum do.…”

Section: Electron Microscopymentioning

confidence: 99%

Amyloid in surgical pathology

Röcken

Sletten

2003

Virchows Archiv

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Amyloid is defined as a proteinaceous tissue deposit that shows a typical green birefringence in polarized light after staining with Congo red, the presence of non-branching linear fibrils of indefinite length with a mean diameter of 10 nm, and a distinct X-ray diffraction pattern consistent with Pauling's model of a cross beta-fibril. Amyloid may deposit locally or may present as a systemic disease. The origin of amyloid is diverse: 25 different fibril proteins have been described so far. The precursor proteins differ from each other in their primary structures and functions. The only common denominator is the propensity to form anti-parallel cross beta-fibrils under certain circumstances. Early diagnosis of amyloid is still a major challenge in surgical pathology. Histological proof can be obtained using Congo-red staining and polarization microscopy. However, small deposits may be difficult to discern, and sensitivity can be improved using fluorescence microscopy. Classification of amyloid is mandatory, since amyloid is treatable and different treatment regimens are applied to different amyloid diseases. This review focuses on the epidemiology, clinical features, pathology and diagnosis of amyloid in surgical pathology.

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“…Zur Bestimmung der Amyloidablagerung in den Organen wird die Biopsie aus dem entsprechenden Organ empfohlen [4,6]. Alternativ kann auch eine Feinnadelpunktion aus dem subkutanen Fettgewebe oder eine Biopsie der Rektum-und Labienschleimhaut zur Beurteilung der generalisierten Amyloidablagerung vorgenommen werden, wobei in bis zu 80% der Fälle positive Ergebnisse erzielt werden [2]. Mikroskopisch stellt sich Amyloid in der Kongorot-Färbung unter dem Polarisationsmikroskop doppelbrechend dar.…”

Section: Diskussionunclassified

Ein seltener Fall von Cholestase und Makrohämaturie bei einem 52-jährigen Patienten

Arkenau

Widjaja

2002

Med Klin

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A highly sensitive method for diagnosis of secondary amyloidosis by labial salivary gland biopsy

Cited by 60 publications

References 19 publications

Labial salivary gland biopsy is a reliable test for the diagnosis of primary and secondary amyloidosis. a prospective clinical and immunohistologic study in 59 patients

Labial salivary gland biopsy is a reliable test for the diagnosis of primary and secondary amyloidosis. a prospective clinical and immunohistologic study in 59 patients

Amyloid in surgical pathology

Ein seltener Fall von Cholestase und Makrohämaturie bei einem 52-jährigen Patienten

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