A histological study of ipsilateral testis after experimentally induced varicocele in albino rats and the role of L-carnitine supplementation

Gawish, Magdy F.; Azmy, Abeer M.; El-Haleem, Manal R. Abd

doi:10.1097/01.ehx.0000395191.16543.ea

Cited by 2 publications

(1 citation statement)

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“…The results of the present study are supported by Eid et al (2016) who stated that L-carnitine had a noticeable protective effect against cisplatin provoked testicular alterations. The results of the current study are also concomitant with the finding of Gawish et al (2011) who observed that the administration of the L-carnitine attenuated the damaging effect of varicocele in the rat testis.…”

Section: Discussionsupporting

confidence: 89%

Possible Protective Role of L-carnitine against Cisplatin-induced Testicular Changes in Adult Male Albino Rats: A Histological and Morphometric Study

Bushra

Bastwrous

2022

Egyptian Academic Journal of Biological Sciences, D. Histology

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INTRODUCTIONThe testis is the male primary reproductive organ. It profits two main functions: secretion of testosterone which is the male sex hormone, and the production of sperms. These functions are key for both maintenances of the male characteristics and preservation of species (Lara et al., 2018).Cisplatin (CIS) is a widely used chemotherapeutic agent. It is used to treat cancer like mesothelioma and osteosarcoma. It has been recommended by the United States Food and Drug Administration since 1978 (Abdel-Moneim, 2014).CIS is an alkylating agent that exerts its effect by persuading DNA cross-links and making breaks in the DNA double strand causing what is called the programmed cell death (PCD) and apoptosis (Reddy et al., 2016). PCD leads to oxidative stress by generating Reactive Oxygen Species and lipid peroxidation, causing cellular necrosis (Fallahzadeh et al., 2017).

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Section: Discussionsupporting

confidence: 89%