A histomorphometric study of cellular layers after hemiepiphyseal stapling on the physeal plate in rabbits

Son, Sumin; Park, Il-Hyung; Oh, Chang-Wug; Lee, Hyun-Joo; Park, Byung‐Chul; Choi, Je‐Yong

doi:10.1007/s00776-012-0317-6

Cited by 3 publications

(8 citation statements)

References 20 publications

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“…Growth plate cartilage injury may lead to the formation of a bony bridge between the epiphysis and metaphysis and, consequently, to the development of an angular deformity as a result of impaired longitudinal bone growth on the side of the bridge. Statis tically, physical injury is the most common cause [7,10,[12][13][14]. If a circumferential part of a growth plate becomes damaged, the remaining intact growth plate does not regenerate eccentrically towards the defect and a soft tissue scar forms that later becomes ossified [15,16,17].…”

Section: Discussionmentioning

confidence: 99%

“…The interpositional material may be biological (fat, autologous rib, joint cartilage) or artificial (silicone, gum, methyl methacrylate). Distraction epiphysiolysis is a surgical procedure performed to rupture a bony bridge [14]. Stem cells have also been used to fill growth plate defects [7,20,21].…”

Section: Discussionmentioning

confidence: 99%

“…Istnieje wiele przyczyn uszkodzeń płytki wzrostowej. Statystycznie najczęstszą przyczyną są urazy [7,10,[12][13][14]. Gdy uszkodzeniu ulega obwodowa część chrząstki wzrostowej, pozostała nieuszkodzona chrząstka wzrostowa nie regeneruje ekscentrycznie w kierunku ubytku, konsekwencją czego jest formowanie blizny łącznotkankowej podlegającej z czasem kostnieniu [15,16,17].…”

Section: Dyskusjaunclassified

“…Materiał interponujący może być: biologiczny (tłuszcz, autologiczne żebro, chrząstka stawowa) lub sztuczny (silikon, guma, metakrylan metylu). Epifizjoliza dystrakcyjna jest procedurą chirurgiczną stosowaną do rozerwania mostu kostnego [14]. Komórki macierzyste były również stosowane jako materiał wypełniający ubytkek w płytce wzrostowej [7,20,21].…”

Section: Dyskusjaunclassified

See 3 more Smart Citations

Orthotopic Autologous Chondrocyte Grafting as a Method of Treatment of Growth Plate Damage in Rabbits

Tomaszewski¹,

Wiktor²,

Gap³

2016

Ortop Traumatol Rehabil

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Dyskusjaunclassified

See 2 more Smart Citations

Orthotopic Autologous Chondrocyte Grafting as a Method of Treatment of Growth Plate Damage in Rabbits

Tomaszewski¹,

Wiktor²,

Gap³

2016

Ortop Traumatol Rehabil

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“…Partial physeal arrest may also be due to infection, tumour, therapeutic irradiation, burn, frostbite, electrical injury, metabolic or haematological abnormality, sensory neuropathy, microvascular ischaemia or insertion of metal. 2 , 3 , 10 , 14 - 16 The size and location of the physeal bridge eventually determines the clinical deformity. When partial physeal arrest is located peripherally, the remainder of the physis usually continues to grow, producing an angular deformity.…”

Section: Discussionmentioning

confidence: 99%

Autogenous cultured growth plate chondrocyte transplantation in the treatment of physeal injury in rabbits

Tomaszewski¹,

Bohosiewicz²,

Gap³

et al. 2014

Bone & Joint Research

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ObjectivesThe aim of this experimental study on New Zealand’s white rabbits was to investigate the transplantation of autogenous growth plate cells in order to treat the injured growth plate. They were assessed in terms of measurements of radiological tibial varus and histological characteristics. MethodsAn experimental model of plate growth medial partial resection of the tibia in 14 New Zealand white rabbits was created. During this surgical procedure the plate growth cells were collected and cultured. While the second surgery was being performed, the autologous cultured growth plate cells were grafted at the right tibia, whereas the left tibia was used as a control group. ResultsHistological examinations showed that the grafted right tibia presented the regular shape of the plate growth with hypertrophic maturation, chondrocyte columniation and endochondral calcification. Radiological study shows that the mean tibial deformity at the left angle was 20.29° (6.25 to 33) and 7.21° (5 to 10) in the right angle. ConclusionThis study has demonstrated that grafting of autogenous cultured growth plate cells into a defect of the medial aspect of the proximal tibial physis can prevent bone bridge formation, growth arrest and the development of varus deformity.Cite this article: Bone Joint Res 2014;3:310–16

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Comparison of two types of fixation for proximal tibial epiphysiodesis: An experimental study in a rabbit model

Bayrak

Duramaz

Kızılkaya³

et al. 2021

Jt Dis Relat Surg

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Objectives: In this study, we describe a novel hemiepiphysiodesis technique to prevent implant-related perichondrial ring injury in a rabbit model. Materials and methods: Proximal tibial epiphyseal plates of a total of 16 white New Zealand rabbits were used for this animal model. The subjects were divided into three equal groups as follows: Group 1 (Kirschner wire [K-wire]/cerclage), Group 2 (8-plate) right-hind legs, Group 3 (Control) left hind legs. Using anteroposterior radiography, the medial slope angle (MSA), articular line-diaphyseal angle (ALDA), and the angle between screws of 8-plate in lateral X-ray tibial slope angle (TSA) were measured. The radiographs were taken early postoperative (Day 1) and on sacrification day (Week 8). The histological evaluation of the perichondrial ring was made on a 7-mm axial section that stained with Safranin O/fast green at X10 magnification. Results: In both K-wire and 8-plate groups, the early postoperative ALDA and TSA were greater than the sacrification ALDA and TSA (p=0.028 and p<0.001, respectively). The early postoperative MSA was lower than the sacrification MSA in groups, (p<0.001). The MSA in the control group was lower than the K-wire and 8-plate groups (p<0.001 and p=0.009; respectively). The perichondrial ring thickness of the K-wire group was greater than the 8-plate group in histological evaluation (p<0.001). Conclusion: Both of the K-wire and 8-plate groups showed similar angulation effects in the proximal tibia, although histologically less damage to the perichondrial ring was observed in the K-wire group, compared to the 8-plate group.

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A histomorphometric study of cellular layers after hemiepiphyseal stapling on the physeal plate in rabbits

Cited by 3 publications

References 20 publications

Orthotopic Autologous Chondrocyte Grafting as a Method of Treatment of Growth Plate Damage in Rabbits

Orthotopic Autologous Chondrocyte Grafting as a Method of Treatment of Growth Plate Damage in Rabbits

Autogenous cultured growth plate chondrocyte transplantation in the treatment of physeal injury in rabbits

Comparison of two types of fixation for proximal tibial epiphysiodesis: An experimental study in a rabbit model

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