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Objectives Predicting the need for surgical treatment among patients with chronic rhinosinusitis (CRS) is challenging. The delta neutrophil index (DNI) has been proposed as a useful laboratory marker of immature granulocytes, which indicates infection or severe inflammation in several diseases. This study evaluated DNI as an early predictor of the need for surgery in patients with CRS. Methods A total of 117 patients diagnosed with CRS were enrolled in this retrospective and observational study. Medical records, including symptoms data, WBC count, ESR level, LUC count, Lund-Mackay scores, and DNI, were reviewed. The receiver operating characteristic (ROC) curves were analyzed to determine the optimal cut-off values for predicting surgery. Results Among 117 patients, 49 patients (41.9%) needed surgical intervention. The areas under the WBC, ESR, LUC, and DNI ROC curves were .571, .600, .592, and .782, respectively. The optimal cut-off value of DNI to predict surgery was .9%. The prognostic precision of DNI showed that the sensitivity was 59.2% and the specificity was 98.5%. In the analysis of risk factors, DNI levels were significantly associated with surgical intervention (odds ratio, 2.22; 95% confidence interval, 1.48-3.34; P < .01). Conclusions The level of DNI, which reflects the severity of the disease, may be a useful predictor for determining the need for surgical intervention in patients with CRS. This is the first literature to verify the role of DNI in upper airway disease.

AO intra-articular steroid injection appears effective for the short-term control of chronic refractory pain arising from the AO joint.

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Objectives: This study aims to examine the effect of adverse childhood experiences (hereafter ACE) on the risk of lifetime suicide attempts. Methods: Cross-sectional data of a sample of 1,396 individuals aged 18-64 years were obtained from the Korean General Social Survey (KGSS) in 2012. Frequency, chi-square analysis, and logistic regression were conducted, utilizing both the SPSS 25.0 and Stata 16. Additionally, population attributable fractions (hereafter PAF) were calculated to determine the proportion of lifetime suicide attempts attributable to ACE. Results: First, parental divorce or separation, witnessing intimate partner violence, and sexual victimization, each increased the risk of lifetime suicide attempts by three times. Compared with those without ACE, the cumulative risk odds of lifetime suicide attempts increased more than five times among those with four or more ACE. Additionally, the estimated PAF for lifetime suicide attempts to cumulative ACE scores ranged from 8% to 14% among the participants. A substantial proportion of suicide attempts was attributable to the increasing number of ACE. Conclusion: The risk of experiencing lifetime suicide attempts increased with increasing ACE scores. ACE prevention actions should carefully consider how ACE may exacerbate the risk of lifetime suicide attempts.