A histopathological study of skin biopsy specimens in a tertiary care hospital with a keynote on clinicopathological correlation

George, Varughese Padinjattadathu; Subramanian, Sowmya; S, Krishnan S Krishnan

doi:10.21276/apalm.2670

Cited by 9 publications

(19 citation statements)

References 9 publications

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“…Leprosy was the most common infection in our study (84% cases). This is consistent with most studies like George et al 11 , Yalla et al 10 , Mittal et al 9 , Kumar et al 8 and Agarwal et al 12 .…”

Section: Discussionsupporting

confidence: 92%

“…In our study, among cases of Hansen disease, most common lesions were Borderline Tuberculoid leprosy with 23.3% cases followed by Tuberculoid Leprosy. Borderline Tuberculoid Leprosy was the most common form of leprosy reported in George et al 11 and Mamatha et al 14 and Roy et al 15 while Tuberculoid Leprosy was the most common lepromatous lesion in Yalla et al 10 and Agarwal et al 12…”

Section: Discussionmentioning

confidence: 97%

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Histomorphological Study of Non Neoplastic Skin Lesions: A Retrospective Approach

Nishal¹,

Bajaj²,

Hathila³

et al. 2022

IJCRR

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Introduction: Non-neoplastic skin disorders encompass a wide spectrum of pathological processes which show age, sex and geographical variation in distribution. Histopathological examination continues to play an invaluable role in diagnosis and management of non neoplastic skin disorders. The present study aims to analyse the histomorphological spectrum of non-neoplastic skin lesions received in a tertiary care hospital, to study their age and sex distribution and to classify the lesions into categories that predict clinically important attributes. Material and Methods: The current study is an observational retrospective study conducted in Department of Pathology in a Tertiary Care Hospital in South Gujrat. 205 skin specimen of non neoplastic skin lesions received over a period of one year (February 2019 to January 2020) were studied. Results: Among 205 cases of non neoplastic skin lesions, male predominance was seen. 21-30 years and 31-40 years were the most common age group. Infectious disorders were the most common category (73 cases) followed by non-neoplastic cutaneous cysts (72 cases). Epidermoid cyst was the common skin lesion closely followed by Leprosy. Borderline Tuberculous was the most frequent subtype of leprosy. Leprosy was most common in 21-30 years age group. Most common vesicobullous disease was Spongiotic Dermatitis followed by Pemphigus Vulgaris. Psoriaform and lichenoid dermatitis showed equal incidence. Conclusion: Heterogeneity in the clinical presentation of skin diseases makes histopathological examination a gold standard technique for final diagnosis. Cutaneous cysts and infectious formed the bulk of cases. Leprosy was the most common non cystic non neoplastic skin lesion of our study.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 97%

Histomorphological Study of Non Neoplastic Skin Lesions: A Retrospective Approach

Nishal¹,

Bajaj²,

Hathila³

et al. 2022

IJCRR

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“…A similar observation is made in other studies. 2,6 Few cases of dermatophyte infection, leishmaniasis and chromoblastomycosis were also diagnosed in our study. Papulosquamous disease was the second most common group of histopathological diagnoses (22.35%).…”

Section: Discussionmentioning

confidence: 62%

“…Other studies also have found Hansen's disease as the most common bacterial infection. 2,4,6 A Nigerian study had reported viral infection as the most common infectious etiology. 7 In Nepal and India, Hansen's disease is still found commonly as shown by our study.…”

Section: Discussionmentioning

confidence: 99%

The Histopathological Spectrum and Clinico-Pathological Concordance in 85 Cases of Skin Biopsy: A Single Center Experience

Jha

Pokharel

2021

Nepal J Dermatol Venereol & Leprol

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Introduction Skin disease is common in developing countries but the spectrum varies widely. Skin biopsy is an important tool in confirming or establishing diagnoses in cases with diagnostic dilemmas. And, there may be a discrepancy between clinical and pathological diagnoses. Objective To determine the spectrum of histological diagnoses in skin disease and to know the consistency between clinical and pathological diagnoses. Materials and methods A retrospective review of histological and clinical diagnoses was done at a multi-specialty hospital. A total of 85 cases were included in the study. Clinical and histological data along with demographic details, the site of the biopsy was noted. Concordance between clinical and pathological diagnosis was determined as concordant, partially concordant and discordant. Results There were 60% female and 40% male patients out of 85 biopsies. The most common age group was 31-40 years and the mean age was 41.24 years. The most common histological spectrum was infectious group in 29.4%, followed by papulosquamous disorders in 22.4% and eczema in 12.9% cases. The concordance between clinical and pathological diagnosis was 60%, while partial concordance was seen in 16.5% and discordance was seen in 23.5% cases. Conclusion Skin biopsy is an important tool in confirming clinical diagnoses. There is a wide variation of histological diagnoses and concordance with clinical diagnoses may be increased with proper clinical history, physical findings and differential diagnosis.

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“…George et al found the clinico-pathological correlation 100% in leprosy, 90.3% in morphea, 85.3% in psoriasis and 82.7% in vesiculobullous diseases in a study on 800 cases. 16 e rate of correlation is di erent in various study cause might be the wide variety of dermatological diseases and lot of factors involved in country to country.…”

Section: Discussionmentioning

confidence: 99%

Clinico-Histopathological Consistency in Dermatological Diseases

et al. 2021

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Skin biopsy for histopathology is the most reliable investigation for diagnosis of skin diseases. The main purpose of skin biopsy is to confirm clinical diagnosis but dermatologists usually looking for the concordance with histopathological report. The aim of the study was to observe the consistency of clinical and histopathological diagnosis of skin diseases. An observational study was conducted on 630 patients that undertaken skin biopsy and that was performed at the Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University from January 2018 to January 2019. Patients who were advised for biopsy by outpatient and inpatient department and the biopsy was done accordingly was included in the study. Finally the inclusion was confirmed when the histopathological report was available. Demographic information, clinical diagnosis, type of biopsy procedure, types of specimen taken and send for histopathological procedure and the histopathological diagnosis was noted in data collection sheet. Histopathological diagnosis and its correlation with clinical diagnosis was assessed for consistency and it was the main outcome measure of the study. The mean age of patients on whom biopsy was performed was 35.14 ±16.57 years and the age range was 5-82 years. Male patients outnumbered female and the male to female ratio was 1.15: 1. Three types of biopsy were performed among them incisional biopsy was the commonest type (93.5%). In most of the cases collected specimen was skin 94.76%, others type of specimens were mucous membrane 2.6%, nail matrix 1.9% and 0.6% specimen was hair follicle. Among the cases 71.43% was diagnosed clinically. The common clinical diagnosis in which biopsy was done was psoriasis and its types 17.77%, lichen planus and its variants 14.12%, the connective tissue diseases 6.19% and infectious diseases 5.39%. In 79.52% cases histopathological diagnosis was done and 68.22% diagnosis was consistent with the clinical diagnosis. The maximum clinico-pathological concordance was found in vesiculo-bullous disease 93.33%. Then connective tissue diseases 79.48%, vasculitides 75% and lichenoid diseases 73.56%. Skin biopsy is a conclusive tool to overcome diagnostic dilemmas in dermatological diseases. The clinico-pathological concordance is assumed lower than the expectation of dermatologists but the collective efforts of dermatologists and pathologists can improve the capacity of diagnosis of biopsy samples. Bangladesh Med J. 2020 Sept; 49(3) : 29-34

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A histopathological study of skin biopsy specimens in a tertiary care hospital with a keynote on clinicopathological correlation

Cited by 9 publications

References 9 publications

Histomorphological Study of Non Neoplastic Skin Lesions: A Retrospective Approach

Histomorphological Study of Non Neoplastic Skin Lesions: A Retrospective Approach

The Histopathological Spectrum and Clinico-Pathological Concordance in 85 Cases of Skin Biopsy: A Single Center Experience

Clinico-Histopathological Consistency in Dermatological Diseases

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