A house fly TNF ortholog Eiger regulates immune defense via cooperating with Toll and Imd pathways

Tang, Ting; Li, Wenqian; Wang, Xiaofen; Wu, Yinjian; Liu, Fengsong

doi:10.1016/j.dci.2018.08.016

Cited by 17 publications

(7 citation statements)

References 31 publications

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“…Previously, the VDR gene is an omnipresent receptor, which is present in various immune cells . The 1α,25-dihydroxy vit-D 3 can activate it, and the activated VDR would stimulate the activity of toll-like receptors in invertebrates . The Toll-like receptors (TLRs)/NF-kB signaling pathway had been reported by many researchers to be found in many vertebrates, but it is scarcely found in crustaceans .…”

Section: Discussionmentioning

confidence: 99%

“…14 The 1α,25-dihydroxy vit-D 3 can activate it, and the activated VDR would stimulate the activity of toll-like receptors in invertebrates. 47 The Toll-like receptors (TLRs)/NF-kB signaling pathway had been reported by many researchers to be found in many vertebrates, but it is scarcely found in crustaceans. 48 The signaling pathway activates the nuclear factor NF-kB's nuclear translocation, and NF-kB is closely related to antibacterial peptide generation in invertebrates.…”

Section: ■ Discussionmentioning

confidence: 99%

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Impact of Dietary Vitamin D₃ Supplementation on Growth, Molting, Antioxidant Capability, and Immunity of Juvenile Chinese Mitten Crabs (Eriocheir sinensis) by Metabolites and Vitamin D Receptor

Liu

Wang

et al. 2021

J. Agric. Food Chem.

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), as an indispensable and fat-soluble nutrient, is associated with skeletal mineralization and health in mammals. However, such associations have not been well studied in economically important crustaceans. Six levels of vit-D 3 with isonitrogenous and isolipidic diets were used to feed Eriocheir sinensis. The range of optimal vit-D 3 requirements is 5685.43−10,000 IU/kg based on growth. The crabs fed 9000 IU/kg vit-D 3 showed the best growth performance. This vit-D 3 dose significantly increased antioxidant capacity in the hepatopancreas and intestine and was optimal for molting and innate immunity via quantitative polymerase chain reaction analysis. Transcriptomics analyses indicate that vit-D 3 could alter protein processing in the endoplasmic reticulum, steroid biosynthesis, and antigen processing and presentation. As shown by the enzyme-linked immunosorbent assay, vit-D 3 could improve vitamin D receptor, retinoic acid receptor, and C-type lectins concentrations. The 1α,25-dihydroxy vit-D 3 content in serum was significantly higher in 3000−9000 IU/kg vit-D 3 . The study suggests that dietary vit-D 3 and its metabolites can regulate molting and innate immunity in crabs.

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Section: Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Impact of Dietary Vitamin D₃ Supplementation on Growth, Molting, Antioxidant Capability, and Immunity of Juvenile Chinese Mitten Crabs (Eriocheir sinensis) by Metabolites and Vitamin D Receptor

Liu

Wang

et al. 2021

J. Agric. Food Chem.

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“…In addition, Eiger has been implicated in the regulation of the expression levels of various AMPs [173,174] and is involved in the control of crystal cell rupture and melanization [175]. Also, in the house fly, Musca domestica, Eiger regulates the innate immune response through coordination of the JNK, Imd and Toll pathways [176].…”

Section: Cytokinesmentioning

confidence: 99%

Endocrine regulation of immunity in insects

2020

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In insects as seen in vertebrates, distinct hormones control the immune response either positively or negatively depending on physiological circumstances. Conversely, the immune system also impacts endocrine regulation. This interplay is itself determined by the environmental cues and organismal homeostatic control. This review surveys different aspects of these intricate relationships with emphasis on the endocrine regulation of immunity in insects, its mechanisms and implications on metabolic adaptation and behaviour.

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“…The TNF family members and their receptors are important pleiotropic cytokines that mediated inflammatory signaling in infectious diseases (Wajant et al, 2003). TNF can coordinate with Imd, Toll, and JNK pathways to regulate the innate immune response through controlling the capacity of phenoloxidase and the expression of antimicrobial peptide genes synergistically (Tang et al, 2019), while the NF-kappa B signaling pathway is crucial for mediating cellular TNF responses (Tanji and Ip, 2005). NF-kappa B is prominently involved in the regulation of immune and inflammatory responses, typically by inducing antiapoptotic gene expression to promote cell survival (Mattson and Meffert, 2006).…”

Section: Activation Of Immune Pathways In Response To Environmental C...mentioning

confidence: 99%

Transcriptome analysis provides insight into adaptive mechanisms of scallops under environmental stress

et al. 2022

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High temperature and hypoxia greatly threaten marine life and aquaculture. Scallops, a diverse and ecologically important group of high economic value, mostly thrive in fluctuating environments, and are vulnerable to environmental stress. In the present study, the molecular response mechanism of scallops to a combination of environmental stressors was investigated via transcriptome analysis of the gill tissues in three scallop species, the Yesso scallop (Patinopecten yessoensis), Zhikong scallop (Chlamys farreri) and bay scallop (Argopecten irradians) that were exposed to transient heat, hypoxia and a combination thereof. The Yesso scallop had the most differentially expressed genes (DEGs) compared with the other two scallop species, indicating the highest sensitivity of the Yesso scallop to environmental stress. With increased temperature and decreased dissolved oxygen, the number of DEGs was greatly increased in the three scallop species, indicative of the enhancement in gene expression regulation in scallops in response to severe environmental changes. Heat and hypoxia had a synergistic effect on scallops. GO and KEGG enrichment analysis of DEGs under different stressors revealed overlapping molecular mechanisms of response in scallops following exposure to heat and hypoxia. Several immune and apoptosis-related pathways were highly enriched in the upregulated DEGs of the three scallops, suggesting that immune system activation and apoptosis promotion occurred in scallops in response to environmental stress. Heat shock proteins (HSPs) were significantly upregulated under heat and hypoxia, which likely assisted in correct protein folding to facilitate the adaption of the scallops to the altered environment. Additionally, the HIF-1 signaling pathway—the key pathway associated with hypoxia response—was triggered by extremely acute environmental changes. Comparative transcriptome analysis revealed 239 positively selected genes among the different scallops, including those involved in immune system and environmental adaptation, suggesting a long-term mechanism of environmental adaptation. The present study provides new insights into the molecular response mechanism in scallops to multiple environmental stressors and improves our understanding of the adaptive mechanisms of marine organisms under changing global climate conditions.

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A house fly TNF ortholog Eiger regulates immune defense via cooperating with Toll and Imd pathways

Cited by 17 publications

References 31 publications

Impact of Dietary Vitamin D₃ Supplementation on Growth, Molting, Antioxidant Capability, and Immunity of Juvenile Chinese Mitten Crabs (Eriocheir sinensis) by Metabolites and Vitamin D Receptor

Impact of Dietary Vitamin D₃ Supplementation on Growth, Molting, Antioxidant Capability, and Immunity of Juvenile Chinese Mitten Crabs (Eriocheir sinensis) by Metabolites and Vitamin D Receptor

Endocrine regulation of immunity in insects

Transcriptome analysis provides insight into adaptive mechanisms of scallops under environmental stress

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A house fly TNF ortholog Eiger regulates immune defense via cooperating with Toll and Imd pathways

Cited by 17 publications

References 31 publications

Impact of Dietary Vitamin D3 Supplementation on Growth, Molting, Antioxidant Capability, and Immunity of Juvenile Chinese Mitten Crabs (Eriocheir sinensis) by Metabolites and Vitamin D Receptor

Impact of Dietary Vitamin D3 Supplementation on Growth, Molting, Antioxidant Capability, and Immunity of Juvenile Chinese Mitten Crabs (Eriocheir sinensis) by Metabolites and Vitamin D Receptor

Endocrine regulation of immunity in insects

Transcriptome analysis provides insight into adaptive mechanisms of scallops under environmental stress

Contact Info

Product

Resources

About

Impact of Dietary Vitamin D₃ Supplementation on Growth, Molting, Antioxidant Capability, and Immunity of Juvenile Chinese Mitten Crabs (Eriocheir sinensis) by Metabolites and Vitamin D Receptor

Impact of Dietary Vitamin D₃ Supplementation on Growth, Molting, Antioxidant Capability, and Immunity of Juvenile Chinese Mitten Crabs (Eriocheir sinensis) by Metabolites and Vitamin D Receptor