A Human Antibody That Binds to the Sixth Ig-Like Domain of VCAM-1 Blocks Lung Cancer Cell Migration In Vitro

Kim, Mi Ra; Jang, Ji Hye; Park, Chang Sik; Kim, Taek Keun; Kim, Youn Jae; Chung, Junho; Shim, Hyunbo; Nam, In-Hyun; Han, Jung Min; Lee, Sukmook

doi:10.3390/ijms18030566

Cited by 14 publications

(12 citation statements)

References 25 publications

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“…It has previously been demonstrated that CD106 is highly overexpressed in lung cancer compared with normal lung tissue, and that it is associated with poor survival. Additionally, the invasive potential of lung cancer cells is significantly weakened by CD106 silencing (57).…”

Section: Discussionmentioning

confidence: 99%

Human epithelial ovarian cancer cells expressing CD105, CD44 and CD106 surface markers exhibit increased invasive capacity and drug resistance

et al. 2019

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The high rate of mortality associated with ovarian cancer (OC) is due in part to the development of resistance to chemotherapy, which allows the resistant tumour cells to invade and metastasise. Clarifying the mechanistic basis for drug resistance may reveal novel avenues for treatment. The present study investigated the mechanism of paclitaxel (PTX) resistance in human epithelial OC by evaluating the expression of stem cell-associated cell surface markers endoglin (CD105), CD44 antigen and vascular cell adhesion molecule 1 (CD106), in association with the malignant potential of the human OC OVCAR3 cell line and its PTX-resistant derivative OC3/TAX300. The expression of CD105, CD44 and CD106 was detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR) and flow cytometry, and cell invasion was evaluated using a Transwell invasion assay. CD105, CD44 and CD106 levels were increased in OC3/TAX300 cells compared with the OVCAR3 cells, as determined by flow cytometry (P<0.01) and RT-qPCR (P<0.05). Additionally, the number of invading cells was increased in the OC3/TAX300 group compared with the OVCAR3 group (54.7±6.65 vs. 31.8±6.55; P<0.01). A western blot analysis of cell surface marker expression in 80 clinical epithelial OC tissue samples, differing in terms of sensitivity to drug treatments, disease stage and degree of differentiation, revealed that high CD105, CD44 or CD106 expression was associated with drug resistance, advanced disease stage, poor differentiation and high rate of recurrence. These data indicated that exposure to high doses of PTX enhanced the stem-like properties of OC cells, which are associated with drug resistance and invasion and lead to poor prognosis due to induced chemoresistance and/or metastasis. Therefore, CD105, CD44 and CD106 may serve as potential stem cell-associated cell surface and prognostic markers, and therapeutic targets, in OC.

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Section: Discussionmentioning

confidence: 99%

Human epithelial ovarian cancer cells expressing CD105, CD44 and CD106 surface markers exhibit increased invasive capacity and drug resistance

et al. 2019

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“…Furthermore, mesothelium VCAM-1 expression was negatively associated with progression-free and overall survival in patients with epithelium ovarian cancers [ 118 ]. VCAM-1 expression also is upregulated in lung cancers [ 119 ]. In addition, VCAM-1 is overexpressed in colorectal cancer, and is associated with lymph node metastasis, clinical stage, and tumor progression in patients with colorectal cancer [ 120 ].…”

Section: Role Of Vcam-1 In Cancermentioning

confidence: 99%

“…In a previous study, we reported that VCAM-1 is highly overexpressed in lung cancer tissues, and that high VCAM-1 expression is closely associated with the poor survival of patients with lung cancer [ 119 ]. In this study, using the siRNA-mediated knockdown of VCAM-1, we identified VCAM-1 as a key molecule regulating the invasion of A549 lung cancer cells.…”

Section: Role Of Vcam-1 In Cancermentioning

confidence: 99%

Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer

Kong

Kim

et al. 2018

IJMS

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477

283

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Tumor necrosis factor alpha (TNFα) is a pro-inflammatory cytokine that triggers the expression of inflammatory molecules, including other cytokines and cell adhesion molecules. TNFα induces the expression of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 (VCAM-1). VCAM-1 was originally identified as a cell adhesion molecule that helps regulate inflammation-associated vascular adhesion and the transendothelial migration of leukocytes, such as macrophages and T cells. Recent evidence suggests that VCAM-1 is closely associated with the progression of various immunological disorders, including rheumatoid arthritis, asthma, transplant rejection, and cancer. This review covers the role and relevance of VCAM-1 in inflammation, and also highlights the emerging potential of VCAM-1 as a novel therapeutic target in immunological disorders and cancer.

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“…Vascular cell adhesion molecule-1 (VCAM-1) is also found expressed in LSECs, which participates in tumor-stromal interactions ( 152 ). Downregulation of VCAM-1 is correlated with suppressed lung cancer cell growth ( 153 ), while VCAM-1 knockdown reduces A549 cells’ ability to migrate ( 154 ).…”

Section: Resultsmentioning

confidence: 99%

Mechanisms and Future of Non-Small Cell Lung Cancer Metastasis

Zhu

Bao²,

Chen

et al. 2020

Front. Oncol.

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Lung cancer, renowned for its fast progression and metastatic potency, is rising to become a leading cause of death globally. It has been long observed that lung cancer is particularly ept in spawning distant metastasis at its early stages, and it can readily colonize virtually any human organ. In recent years, cancer research has shed light on why lung cancer is endowed with its exceptional ability to metastasize. In this review, we will take a comprehensive look at the current research on lung cancer metastasis, including molecular pathways, anatomical features and genetic traits that make lung cancer intrinsically metastatic, as we go from lung cancer’s general metastatic potential to the particular metastasis mechanisms in multiple organs. We highly concerned about the advanced discovery and development of lung cancer metastasis, indicating the importance of lung cancer specific gene mutations, heterogeneity or biomarker discovery, and discussing potential opportunities and challenges. We will also introduce some current treatments that targets certain metastatic strategies of non-small cell lung cancer (NSCLC). Advances made in these regards could be critical to our current knowledge base of lung cancer metastasis.

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A Human Antibody That Binds to the Sixth Ig-Like Domain of VCAM-1 Blocks Lung Cancer Cell Migration In Vitro

Cited by 14 publications

References 25 publications

Human epithelial ovarian cancer cells expressing CD105, CD44 and CD106 surface markers exhibit increased invasive capacity and drug resistance

Human epithelial ovarian cancer cells expressing CD105, CD44 and CD106 surface markers exhibit increased invasive capacity and drug resistance

Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer

Mechanisms and Future of Non-Small Cell Lung Cancer Metastasis

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