A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice

CD25+ regulatory cells from HLA-DQ8 transgenic mice are capable of modulating collagen-induced arthritis

“…Besides being susceptible to CIA [6], it is predisposed to experimental autoimmune uveitis [19], autoimmune thyroiditis [23], myasthenia gravis, and spontaneous psoriatic arthritis [18], among others. To determine if this autoimmune-prone phenotype was the result of a deficient CD25 ϩ T regulatory repertoire, we examined CD4 ϩ CD25 ϩ T regulatory cells isolated from DQ8.A␤ 0 transgenic mice.…”

Protective effect of pristane on experimental autoimmune uveitis

“…The adoptive transfer of pathogenic T cells can reproduce EAU in healthy recipients, but not the passive transfer of hyper-immune serum [31]. Moreover, the passive transfer of specific auto-antibodies may exert a synergistic effect with T cells on EAU when associated with an adoptive transfer of T cells [32]. Thus, immunoglobulins that cannot penetrate into a healthy eye, can amplify the EAU once the hemato-retinal barrier has been damaged following the local influx of inflammatory cells at the onset of the disease.…”

Cutting-Edge Issues in Autoimmune Uveitis

“…This brings up the interesting clue for facing HLA class II alleles such as DR4(DRB1 *0401), DR3 (DRB1 *0301), DQ6(DQB1*0601), and DQ8 (DQB1*0302) candidates for antigen-specific biomarkers and therapeutic targets for human uveitis [54]. "Spontaneous" uveitis occurs when there is a situation that induces specific T cell affinity and/or frequency, as in the mice lacking AIRE (autoimmune regulator, a transcriptional regulator).…”