A hybrid coating of polydopamine and nano-hydroxyapatite enhances surface properties of 3D printed poly(lactic-co-glycolic acid) scaffolds

Chen, Weitong; Nichols, Luke; Teer, Landon; Clinton, Kailey; Priddy, Lauren B.

doi:10.1007/s10853-022-07442-y

Cited by 5 publications

(1 citation statement)

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“…Adding the bioceramics in the bulk polymer causes them to be entrapped, and most of the filler is not close to the surface of the produced filaments, so it cannot come in contact with cells and as a result, an excessive amount of filler is used. To overcome this, a bioactive ceramic coating can be applied on the scaffold [10,[22][23][24][25]. These coatings provide the scaffold with bioactivity and roughness that improves cell growth [26][27][28].…”

Section: Graphical Abstract Introductionmentioning

confidence: 99%

3D printed poly(lactic acid)-based nanocomposite scaffolds with bioactive coatings for tissue engineering applications

et al. 2023

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In this work, the effect of two different types of bioactive coatings on the properties of 3D printed poly(lactic acid)/montmorillonite (PLA/MMT) nanocomposite scaffolds was examined. To improve their suitability for bone tissue engineering applications, the PLA nanocomposite scaffolds were coated with (i) ordered mesoporous Strontium bioglass (SrBG) and (ii) SrBG and nanohydroxyapatite (nHA) using a simple dip coating procedure. The effect of the coatings on the morphology, chemical structure, wettability and nanomechanical properties of the scaffolds was examined. The hydrophilicity of PLA nanocomposite scaffolds increased after the SrBG coating and increased even more with the SrBG/nHA coating. Moreover, in the case of PLA/MMT/SrBG/nHA 3D printed scaffolds, the elastic modulus increased by ~ 80% and the hardness increased from 156.9 ± 6.4 to 293.6 ± 11.3 MPa in comparison with PLA. Finally, the in vitro biocompatibility and osteogenic potential were evaluated using bone marrow-derived stem cells. The coating process was found to be a fast, economical and effective way to improve the biomineralization and promote the differentiation of the stem cells toward osteoblasts, in comparison with the neat PLA and the PLA/MMT nanocomposite scaffold. Graphical abstract

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