The provision of goods shuttle services sometimes faces several constraints, such as the limitation on the number of vehicles, vehicle capacity, and service time, or the vehicle used has single transport access. To avoid losses, a strategy is needed in determining the optimal route and policy for arranging goods in the vehicle especially if there are two types of goods involved. Traveling Salesman Problem and Pick-up and Delivery with Handling Costs and Time Windows (TSPPDHTW) is a model of an optimization problem that aims to minimize the total travel and goods handling costs in the goods pick-up and delivery with the constraints previously mentioned. Solving that model using the exact method requires a very long computation time so it’s not effective to be implemented in real-life. This study aims to develop a (meta)heuristic based on Ant Colony Optimization (ACO) and Tabu Search (TS) to be ACOTS to solve TSPPDHTW with reasonable computation time. The development is carried out by adding functions of clustering, evaluating constraints, cutting tours, arranging of goods, and evaluating moves on the TS, as well as modifying transition rules. The result has a deviation of about 22% and 99.99% less computational time than the exact method.