A hybrid hydrogel constructed using drug loaded mesoporous silica and multiple response copolymer as an intelligent dressing for wound healing of diabetic foot ulcers

Abstract

Traditional wound dressings have poor mechanical properties and single function, which cannot achieve rapid healing of diabetes wounds in a unique physiological microenvironment. In order to develop multifunctional hydrogel dressings...

Recent advances of hydrogels as smart dressings for diabetic wounds

“…121 Similarly, Zhang and colleagues prepared a pH/glucose-responsive hydrogel for delivering tetracycline using benzeneboric acid groups. 122 To reduce the emergence of resistant bacteria, adding inorganic metal antibiotics and natural extracts to hydrogels is also a common strategy. Inorganic metal antibiotics and natural extracts have broad and stable antibacterial activities that involve multiple mechanisms of action, including destroying bacterial cell membranes, attacking bacterial DNA and proteins, and generating ROS, making them less likely to produce bacterial resistance.…”

SBA-15- and SBA-16-Functionalized Silicas as New Carriers of Niacinamide

“…Since 2001, when Vallet-Regi and co-workers [15] described the use of ordered mesoporous material of the MCM-41 type as a carrier in active substance delivery systems, great opportunities have opened up, mainly for pharmaceutical science. That work sparked the interest of the researchers and initiated the use of new silica-based mesoporous materials as carriers for selected active substances [16][17][18][19][20][21]. This trend may also be observed in the context of food ingredients [22][23][24][25][26], because the nanostructured amorphous silica has been positively evaluated as a food additive that does not cause any relevant systemic or local toxicity after oral exposure [1,27].…”

Multifunctional nanocomposites mediated novel hydrogel for diabetic wound repair

“…[38][39][40] Therefore, they are an excellent comprehensive platform for treating diabetic wounds. Among them, nanocomposite-hydrogels 41,42 have received more and more research attention. At present, they are mainly constructed in the following ways: [43][44][45][46][47] (1) the synthesized nanocomposite is formed by physical mixing with a hydrogel; (2) at low temperature, the synthesized nanocomposite is mixed with temperature-sensitive hydrogel, and then heated to form a nanocomposite-hydrogel; (3) a nanocomposite-hydrogel is synthesized by generating reactive nanoparticles in a preformed gel.…”