A hybrid nanocomposite of CeO<sub>2</sub>–ZnO–chitosan as an enhanced sensing platform for highly sensitive voltammetric determination of paracetamol and its degradation product <i>p</i>-aminophenol

Almandil, Noor B.; Ibrahim, Mohamed; Ibrahim, Hossieny; Kawde, Abdel‐Nasser; Shehatta, Ibrahim; Akhtar, Sultan

doi:10.1039/c9ra01587f

Cited by 30 publications

(12 citation statements)

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“…Thus, the amperometric sensor can sense the analyte with superior sensitivity with enhanced current many orders of magnitude greater than DPV. , The performance of the present sensor with the recently reported sensors against ACAP is compared and summarized in Table . When compared to the reported methods, the present sensor offered inspiring sensitivity and LOD with a linear range of detection of 0.1–1900 μM. − ,− …”

Section: Resultsmentioning

confidence: 99%

“…These methods are relatively expensive and time-consuming, require presample preparation, and have very complicated handling procedures. Notwithstanding the above-mentioned analytical techniques, an electrochemical approach is economically viable, portable, quick responding, time-saving, more efficient, of higher sensitivity, excellent selectivity, simplicity, and good practicability for the accurate determination of ACAP. − Moreover, electrochemical sensing devices and chemically modified electrodes have several advantages in vast of areas including proteomic detections, biological sensors, molecular biology, nanotechnology and nanoscience, food and pharmaceutical drug analysis, and agricultural and environmental inspections.…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Scaffold Based on Silver Phosphate Nanoparticles for the Quantification of Acetaminophen in Body Fluids and Pharmaceutical Formulations

Gowthaman

Lim

Shankar

2019

ACS Appl. Nano Mater.

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Herein, we present the electrochemical scaffold for the quantification of acetaminophen (ACAP) using a silver phosphate nanoparticle (Ag−P NP) fabricated screen-printed carbon electrode (SPCE). The Ag−P NPs were synthesized by a facile method through simply refluxing the reaction mixture of AgNO 3 and Na 2 HPO 4 at 120 °C in the presence of citric acid followed by calcination. The obtained Ag−P NPs were characterized by Fourier transform infrared (FT-IR) and UV− vis diffused reflectance spectroscopies, X-ray diffraction (XRD), and electron microscopic tools. The as-prepared Ag−P NPs exhibited the bandgap energy of 2.2 eV, and the prepared Ag−P NPs have a sphere-like morphology with 13 nm average size. The main strategy of this study lies in providing the electrocatalytic oxidation of ACAP at the surface of the Ag−P NPs modified electrode. The developed sensor was applied to determine ACAP from commercial drugs and human fluids. The Ag-P NPs modified electrode detects ACAP in the linear concentration of 0.1−1900 μM with the lowest detection limit of 0.39 nM (S/N = 3) with the superior sensitivity of 2244.4 μA/μM•cm 2 . Further, the developed sensor showed excellent specificity, sensitivity, reproducibility, and stability compared to the previously reported sensors. Finally, the developed sensor has been exploited to testify the practicability by determining the concentration of ACAP from pharmaceutical samples and human fluids. The synthesized Ag−P NPs were also utilized for antibacterial studies against Staphylococcus aureus and Aspergillus niger.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrochemical Scaffold Based on Silver Phosphate Nanoparticles for the Quantification of Acetaminophen in Body Fluids and Pharmaceutical Formulations

Gowthaman

Lim

Shankar

2019

ACS Appl. Nano Mater.

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“…Carbon-based metal nanoparticles have attracted considerable attention due to their mechanical and thermal properties and their ability for electrode modifications [13,14]. Because of these properties, metal and metal oxide nanoparticles have been used successfully for increasing carbon paste electrode sensitivity toward various electroanalytical applications [15,16]. It was found in the literature that pure Cu2ONPs [11] and Cu2ONPs supported on carbon materials were applied successfully in different voltametric determinations [17,18].…”

Section: Introductionmentioning

confidence: 99%

Graphite Studded with Facile-Synthesized Cu2O Nanoparticle-Based Cubes as a Novel Electrochemical Sensor for Highly Sensitive Voltametric Determination of Mebeverine Hydrochloride

et al. 2021

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Herein, a feasible chemical reduction method followed by intensive mixing was applied for the preparation of an attractive material based on graphite studded with cuprous oxide nanoparticle-based cubes (Cu2ONPs–C@G). Transmission electron microscope (TEM), scanning electron microscope (SEM), X-ray diffraction (XRD) and cyclic voltammetry (CV) were utilized for characterization. Cuprous oxide nanoparticles (Cu2ONPs), with a diameter range mainly distributed from 4 to 20 nm, aggregate to form microcubes (Cu2ONPs–C) with an average diameter of about 367 nm. Paste electrode was prepared using Cu2ONPs–C@G (Cu2ONPs–C@G/PE) for voltametric quantification of the musculotropic antispasmodic drug: mebeverine hydrochloride (MEB). The electrochemical behavior of MEB was studied using CV, and the optimum analytical parameters were investigated using square wave adsorptive anodic stripping voltammetry (SWAdASV). Moreover, density functional theory (DFT) was used to emphasize the ability of MEB to form a complex with Cu2+, confirming the suggested electrochemical behavior of MEB at Cu2ONPs–C@G/PE. With good stability and high reproducibility, SWAdASV of Cu2ONPs–C@G/PE shows successful quantification of MEB over the concentration range of 5.00 × 10−11–1.10 × 10−9 M with lower limit of detection (LOD) and lower limit of quantification (LOQ) values of 2.41 × 10−11 M and 8.05 × 10−11 M, respectively. Finally, accurate quantification of MEB in dosage forms (tablets) and biological fluids (spiked human urine and plasma samples) was achieved using Cu2ONPs-C@G/PE.

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“…P-aminophenol is a fundamental material for the synthesis of paracetamol. It is also an intermediate molecular for the hydrolysis of paracetamol within the human body (Almandil et al, 2019;Chu, Jiang, Tian, & Ye, 2008;Riggin, Schmidt, & Kissinger, 1975). Furthermore, under poor storage conditions, paracetamol drug formulations may degrade to form harmful compounds for the human organism such, as paminophenol (Abdolkader, 2011;Song & Chen, 2001).…”

Section: Introductionmentioning

confidence: 99%

Oxidative Coupling-Base Reaction for the Indirect Spectrophotometric Determination of Paracetamol in Drug Formulations

Thanoon

Raheed

Hasan

2021

IJONEST

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A simple, rapid, and specific spectrophotometric method was developed for the determination of paracetamol in pure form and drug formulations. The method depended on the hydrolysis of paracetamol to p-aminophenol, which, oxidized under the effect of dissolved oxygen to benzoquinoneimine. In the alkaline medium, benzoquinoneimine reacts with Methyldopa to produce a high stabile indophenol dye. The absorbance was measured at 580 nm, and the molar absorptivity was found to be 7.75 x 10-5 L/(mol cm). Paracetamol was determined in pharmaceutical products in the 10–100 μg.mL-1 concentration range with a detection limit of 1.5 μg.mL-1 PAP. The developed method can be applied to the determination of both paracetamol and p-aminophenol in the presence of each other without prior separation. The proposed method is successfully employed for the determination of paracetamol in various synthetic mixtures and pharmaceutical preparations. Our obtained results were statistically compared with those given by the similar methods and the procedures evaluated as regards to both figures of merit and ease of applicability.

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A hybrid nanocomposite of CeO₂–ZnO–chitosan as an enhanced sensing platform for highly sensitive voltammetric determination of paracetamol and its degradation product p-aminophenol

Abstract: A highly selective electrochemical sensor was fabricated based on CeO2–ZnO–chitosan hybrid nanocomposite modified electrode and was successfully applied for the determination of PAR in pharmaceutical formulations.

Cited by 30 publications

References 54 publications

Electrochemical Scaffold Based on Silver Phosphate Nanoparticles for the Quantification of Acetaminophen in Body Fluids and Pharmaceutical Formulations

Electrochemical Scaffold Based on Silver Phosphate Nanoparticles for the Quantification of Acetaminophen in Body Fluids and Pharmaceutical Formulations

Graphite Studded with Facile-Synthesized Cu2O Nanoparticle-Based Cubes as a Novel Electrochemical Sensor for Highly Sensitive Voltametric Determination of Mebeverine Hydrochloride

Oxidative Coupling-Base Reaction for the Indirect Spectrophotometric Determination of Paracetamol in Drug Formulations

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A hybrid nanocomposite of CeO2–ZnO–chitosan as an enhanced sensing platform for highly sensitive voltammetric determination of paracetamol and its degradation product p-aminophenol

Abstract: A highly selective electrochemical sensor was fabricated based on CeO2–ZnO–chitosan hybrid nanocomposite modified electrode and was successfully applied for the determination of PAR in pharmaceutical formulations.

Cited by 30 publications

References 54 publications

Electrochemical Scaffold Based on Silver Phosphate Nanoparticles for the Quantification of Acetaminophen in Body Fluids and Pharmaceutical Formulations

Electrochemical Scaffold Based on Silver Phosphate Nanoparticles for the Quantification of Acetaminophen in Body Fluids and Pharmaceutical Formulations

Graphite Studded with Facile-Synthesized Cu2O Nanoparticle-Based Cubes as a Novel Electrochemical Sensor for Highly Sensitive Voltametric Determination of Mebeverine Hydrochloride

Oxidative Coupling-Base Reaction for the Indirect Spectrophotometric Determination of Paracetamol in Drug Formulations

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A hybrid nanocomposite of CeO₂–ZnO–chitosan as an enhanced sensing platform for highly sensitive voltammetric determination of paracetamol and its degradation product p-aminophenol