Graphite Studded with Facile-Synthesized Cu2O Nanoparticle-Based Cubes as a Novel Electrochemical Sensor for Highly Sensitive Voltametric Determination of Mebeverine Hydrochloride

Abstract

Herein, a feasible chemical reduction method followed by intensive mixing was applied for the preparation of an attractive material based on graphite studded with cuprous oxide nanoparticle-based cubes (Cu2ONPs–C@G). Transmission electron microscope (TEM), scanning electron microscope (SEM), X-ray diffraction (XRD) and cyclic voltammetry (CV) were utilized for characterization. Cuprous oxide nanoparticles (Cu2ONPs), with a diameter range mainly distributed from 4 to 20 nm, aggregate to form microcubes (Cu2ONPs–C) with an average diameter of about 367 nm. Paste electrode was prepared using Cu2ONPs–C@G (Cu2ONPs–C@G/PE) for voltametric quantification of the musculotropic antispasmodic drug: mebeverine hydrochloride (MEB). The electrochemical behavior of MEB was studied using CV, and the optimum analytical parameters were investigated using square wave adsorptive anodic stripping voltammetry (SWAdASV). Moreover, density functional theory (DFT) was used to emphasize the ability of MEB to form a complex with Cu2+, confirming the suggested electrochemical behavior of MEB at Cu2ONPs–C@G/PE. With good stability and high reproducibility, SWAdASV of Cu2ONPs–C@G/PE shows successful quantification of MEB over the concentration range of 5.00 × 10−11–1.10 × 10−9 M with lower limit of detection (LOD) and lower limit of quantification (LOQ) values of 2.41 × 10−11 M and 8.05 × 10−11 M, respectively. Finally, accurate quantification of MEB in dosage forms (tablets) and biological fluids (spiked human urine and plasma samples) was achieved using Cu2ONPs-C@G/PE.

Potentiometric determination of mebeverine hydrochloride antispasmodic drug based on molecular docking with different ionophores host–guest inclusion as a theoretical study

“…1 A comprehensive study of the literature revealed the dominance of analytical methods for MBV, including spectrophotometric, 2-11 HPLC, [12][13][14][15][16][17][18] uorometric, 19,20 and electrochemical methods. [21][22][23][24][25][26][27] Although these methods provided a high level of specicity, they are unable to apply rapid in situ detection of MBV. Moreover, these previously described methods still had several limitations, such as the need to use a lot of expensive, hazardous organic reagents that would hurt the environment.…”

Spectrophotometric Determination of Active Compounds in an Antihypertensive Formulation by Haar-CWT Method

“…Furthermore, these combined unit methods involve high costs and time for analysis [4][5][6]. Analytical methods such as spectrophotometry [7], mass-spectrometry [8], chromatography [9] and electrophoresis [10], electrochemistry [11] and their joint devices have been used for analytical purposes. Because of the disadvantages of the mentioned separation techniques or combination analyzers, analytical chemists opt to use spectroscopic methods (rather than separation techniques) to enable rapid analysis at low cost.…”

Spectrophotometric Determination of Losartan Potassium and Hydrochlorothiazide in tablets by Wavelet Transform Approach

“…Furthermore, these combined unit methods involve high costs and time for analysis [4][5][6]. Analytical methods such as spectrophotometry [7], massspectrometry [8], chromatography [9] and electrophoresis [10], electrochemistry [11] and their joint devices have been used for analytical purposes. Herewith the disadvantages of the mentioned separation techniques or combination analyzers, analytical chemists opt to use spectroscopic methods (rather than separation techniques) to enable rapid analysis at low cost.…”