A variety of voltammetric methods have been carried out for determination of brexpiprazole (BRX) using cyclic voltammetry (CV) and two different type anodic stripping methods; differential pulse (AS-DP) and square wave (AS-SWV) at modified carbon paste electrode with gold nanoparticles (AuNPs-CPEs). Additionally, electrochemical impedance spectroscopy (EIS) technique has been utilized for characterization of the different electrodes. Electrochemical oxidation behavior of BRX shows an irreversible anodic peak at 0.88 V versus Ag/AgCl, in Britton-Robinson buffer (BR) at pH 4.0, 50s preconcentration time and −0.5 deposition potential. Rectilinear relationship between the peak current versus concentration was obtained over the ranges of 1.32 × 10 −6 -6.45 × 10 −6 and 1.32 × 10 −7 -6.45 × 10 −7 mol L −1 for AS-DP and AS-SWV respectively. The lowest concentration that can be detected for both for AS-DP and AS-SWV was 3.99 × 10 −7 and 3.32 × 10 −8 mol L −1 respectively; the utilized methods have been devoted adequately for the estimation of BRX in its pure and dosage form.

No abstract

A new chemically optimized screen-printed electrode modified with a cobalt-doped α-Mn₂O₃ nanostructure on carbon nanotube paste (α-Mn₂O₃:Co@CNTs) has been constructed for the recognition of cyclobenzaprine hydrochloride.