A hybrid thin-film/CMOS fluorescence contact imager

Singh, Ritu Raj; Ho, Derek; Nilchi, Alireza; Genov, Roman; Gulak, Glenn

doi:10.1109/iscas.2009.5118293

Cited by 3 publications

(2 citation statements)

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“…D ETECTION of fluorescence with a configuration consisted of excitation light source, micro-fluidic chip, optical filters, and complementary metal-oxide-semiconductor (CMOS) sensors, plays a key role in the quantitative analysis of nucleic acid by polymerase chain reaction (PCR) [1], [2], [3], [4], [5], [6], [7]. In this special era that the COVID-19 has been threatening public health all over the world for almost 3 years since the end of year 2019, a rapid responding, portable, and high Wenbing Li is with the Shanghai Industrial µTechnology Research Institute, Shanghai 201899, China (e-mail: quentinlee08@foxmail.com).…”

Section: Introductionmentioning

confidence: 99%

Symmetrical Coupling Multi-Cavity Bandpass Filter for CMOS Compatible Fluorescence Detection

Chen

2022

IEEE Photonics J.

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Section: Introductionmentioning

confidence: 99%

Symmetrical Coupling Multi-Cavity Bandpass Filter for CMOS Compatible Fluorescence Detection

Chen

2022

IEEE Photonics J.

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“…A human DNA microarray and the Cy3 fluorescent dye are utilized to validate the performance of the microsystem. Preliminary results have been reported in [25]. On-chip temporal and spatial signal processing is employed to perform excitation light artifact removal and DNA spot contour identification to further improve DNA image quality and analysis accuracy.…”

Section: Introductionmentioning

confidence: 99%

A CMOS/Thin-Film Fluorescence Contact Imaging Microsystem for DNA Analysis

Singh

Nilchi

et al. 2010

IEEE Trans. Circuits Syst. I

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A hybrid CMOS/thin-film microsystem for fluorescence contact imaging is presented. The microsystem integrates a high-performance optical interference filter and a 128 128 pixel active pixel sensor fabricated in a standard 0.35-m CMOS technology. The thin-film filter has an optical density greater than 6.0 at the wavelength of interest, providing adequate excitation rejection to the 532-nm solid-state laser. Microsystem performance is experimentally validated by imaging spots of Cyanine-3 fluorophore, conventionally used in DNA detection. The emission intensity as a function of fluorophore concentration is measured with an estimated sensitivity of 5000 fluorophore m 2 . A human DNA microarray has been imaged with the sensor prototype.

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