Well ER-5-3-2 is part of a well network designed to monitor long-term water levels and radionuclide concentrations downgradient from underground nuclear tests that occurred in Frenchman Flat, an area of the U.S. Department of Energy Nevada National Security Site in southern Nevada. Interpretation of monitoring records for well ER-5-3-2 was confounded by previously unexplained water-level fluctuations in the well hydrograph. This study integrated geologic, hydrologic, and water-chemistry data to evaluate potential stresses and hydrologic conditions that likely affected the well ER-5-3-2 hydrograph. Numerical groundwater models were applied to evaluate four model scenarios: (1) wellbore leakage without recharge, (2) wellbore leakage with recharge, (3) equilibration to vertical heterogeneities between shallow (low transmissivity) and deep (higher transmissivity) carbonate zones, and (4) equilibration to lateral heterogeneities in carbonate rocks.Meteoric recharge was not the cause of the 21-foot (ft) water-level rise in well ER-5-3-2 from 2001 to 2011 or the 4-ft decline from 2012 to 2016. Based on observed water-level fluctuations in nearby wells, the water-level rise and decline from recharge for these periods was less than 3 and 1 ft, respectively. The lateral-heterogeneity scenario is based on the assumption that the 21-ft water-level rise from 2001 to 2011 was a natural water-level reequilibration following the pumping-induced depressurization of a large volume of high transmissivity and low-storage carbonate rock that is surrounded by low transmissivity and high-storage carbonate rock. The lateral-heterogeneity scenario was discounted because simulated water levels cannot match the well ER-5-3-2 hydrograph. Underground nuclear testing and temperature effects were discounted based on hydraulic connections and water-temperature data.Wellbore-leakage scenarios are based on the assumption that the water-level rise was sustained from leakage rates required to cause a localized mounding in the carbonate system near well ER-5-3-2, where the carbonate transmissivity is 530 square feet per day. Even though simulated and measured water levels compare favorably for scenarios of wellbore leakage with and without recharge, large volumes (178-184 million gallons) of