A Hyperspectral Imaging System for Mapping Haemoglobin and Cytochrome-c-Oxidase Concentration Changes in the Exposed Cerebral Cortex

Giannoni, Luca; Lange, Frédéric; Sajic, Marija; Smith, Kenneth J.; Tachtsidis, Ilias

doi:10.1109/jstqe.2021.3053634

Cited by 15 publications

(14 citation statements)

References 23 publications

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“… 52 Examples of supercontinuum-based hyperspectral systems have recently been described elsewhere. 53 , 54 …”

Section: Hardware Developmentsmentioning

confidence: 99%

“…52 Examples of supercontinuum-based hyperspectral systems have recently been described elsewhere. 53,54 The detection arm of a hyperspectral system is often a single camera (either CCD or CMOSbased technology). 49 In contrast, bNIRS devices are exclusively based on the utilization of a spectrometer that incorporates a light wavelength dispersion grating with a camera that most often has been a CCD-based camera.…”

Section: Hyperspectral and Broadband Nirsmentioning

confidence: 99%

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Optical imaging and spectroscopy for the study of the human brain: status report

et al. 2022

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. This report is the second part of a comprehensive two-part series aimed at reviewing an extensive and diverse toolkit of novel methods to explore brain health and function. While the first report focused on neurophotonic tools mostly applicable to animal studies, here, we highlight optical spectroscopy and imaging methods relevant to noninvasive human brain studies. We outline current state-of-the-art technologies and software advances, explore the most recent impact of these technologies on neuroscience and clinical applications, identify the areas where innovation is needed, and provide an outlook for the future directions.

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“… 52 Examples of supercontinuum-based hyperspectral systems have recently been described elsewhere. 53 , 54 …”

Section: Hardware Developmentsmentioning

confidence: 99%

Section: Hyperspectral and Broadband Nirsmentioning

confidence: 99%

Optical imaging and spectroscopy for the study of the human brain: status report

et al. 2022

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“…Giannoni, et al using Monte Carlo (MC) simulations to demonstrate the applicability of HSI for mapping and quantifying changes in HBO 2 , HHb, and oxCCO concentrations in exposed cerebral cortex under hypoxia ( Giannoni et al, 2020 ). Soon after, the same research group firstly present a novel HSI system for imaging and monitoring of HbO 2 , HHb and CCO in exposed mouse cerebral cortex under different oxygenation state environments (hyperoxia, hypoxia and anoxia) ( Giannoni et al, 2021 ). In this work, the same 8 bands of NIR spectral and 3 bands of visible wavelengths are combined to enhance the image contrast of hemoglobin and oxCCO.…”

Section: Hyperspectral Imaging In Cerebral Diagnosismentioning

confidence: 99%

Review on the Application of Hyperspectral Imaging Technology of the Exposed Cortex in Cerebral Surgery

Yang

et al. 2022

Front. Bioeng. Biotechnol.

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The study of brain science is vital to human health. The application of hyperspectral imaging in biomedical fields has grown dramatically in recent years due to their unique optical imaging method and multidimensional information acquisition. Hyperspectral imaging technology can acquire two-dimensional spatial information and one-dimensional spectral information of biological samples simultaneously, covering the ultraviolet, visible and infrared spectral ranges with high spectral resolution, which can provide diagnostic information about the physiological, morphological and biochemical components of tissues and organs. This technology also presents finer spectral features for brain imaging studies, and further provides more auxiliary information for cerebral disease research. This paper reviews the recent advance of hyperspectral imaging in cerebral diagnosis. Firstly, the experimental setup, image acquisition and pre-processing, and analysis methods of hyperspectral technology were introduced. Secondly, the latest research progress and applications of hyperspectral imaging in brain tissue metabolism, hemodynamics, and brain cancer diagnosis in recent years were summarized briefly. Finally, the limitations of the application of hyperspectral imaging in cerebral disease diagnosis field were analyzed, and the future development direction was proposed.

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“…In the early 2000s, a system based on a home-made SC generation associated with an imaging spectrometer coupled with a streak camera was developed and used to monitor the cerebral hemodynamic of songbirds [80,81]. More recently, the UCL team have developed a system aiming at investigating both the cerebral hemodynamic and metabolic response (via oxCCO) of the exposed cortex of rodents [25]. In this work, a commercial SCL was used in combination with a dispersive prism, for the emission, and a sCMOS camera, as a detector, to record 11 images (11 wavelengths) of the exposed cortex in less than 0.3 s/wavelength.…”

Section: Novel Instrument Developementmentioning

confidence: 99%

The Use of Supercontinuum Laser Sources in Biomedical Diffuse Optics: Unlocking the Power of Multispectral Imaging

2021

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Optical techniques based on diffuse optics have been around for decades now and are making their way into the day-to-day medical applications. Even though the physics foundations of these techniques have been known for many years, practical implementation of these technique were hindered by technological limitations, mainly from the light sources and/or detection electronics. In the past 20 years, the developments of supercontinuum laser (SCL) enabled to unlock some of these limitations, enabling the development of system and methodologies relevant for medical use, notably in terms of spectral monitoring. In this review, we focus on the use of SCL in biomedical diffuse optics, from instrumentation and methods developments to their use for medical applications. A total of 95 publications were identified, from 1993 to 2021. We discuss the advantages of the SCL to cover a large spectral bandwidth with a high spectral power and fast switching against the disadvantages of cost, bulkiness, and long warm up times. Finally, we summarize the utility of using such light sources in the development and application of diffuse optics in biomedical sciences and clinical applications.

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A Hyperspectral Imaging System for Mapping Haemoglobin and Cytochrome-c-Oxidase Concentration Changes in the Exposed Cerebral Cortex

Cited by 15 publications

References 23 publications

Optical imaging and spectroscopy for the study of the human brain: status report

Optical imaging and spectroscopy for the study of the human brain: status report

Review on the Application of Hyperspectral Imaging Technology of the Exposed Cortex in Cerebral Surgery

The Use of Supercontinuum Laser Sources in Biomedical Diffuse Optics: Unlocking the Power of Multispectral Imaging

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