A<i>Candida</i>‐specific antibody in patients with vaginitis

Ott, Alewijn; Franklyn, Kathleen M.; Warmington, John R.; Ashman, R. B.

doi:10.5694/j.1326-5377.1990.tb125254.x

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…It is important to recognize that even in carefully matched patients with culture-proven infections, antigen processing and host responses may vary. This is exemplified by the detection of antibodies to enolase, a protein that acts as an immunodominant antigen in both humans (131,349) and mice (325), in only a proportion of a cohort of patients with Candida vaginitis, grouped according to the presence or absence of active infection (247).…”

Section: Chronic Vaginal Candidiasismentioning

confidence: 99%

Production and function of cytokines in natural and acquired immunity to Candida albicans infection.

Ashman¹,

Papadimitriou²

1995

Microbiological Reviews

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Section: Chronic Vaginal Candidiasismentioning

confidence: 99%

Production and function of cytokines in natural and acquired immunity to Candida albicans infection.

Ashman¹,

Papadimitriou²

1995

Microbiological Reviews

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“…Vaginal immunization with C. albicans protected pseudoestrous mice against experimental vaginal infection (11), and local cell-mediated immunity may have a role in host defense against this condition (16). The role of a specific antibody in host defense against Candida vaginitis has been questioned because patients with this condition are likely to have antibodies of various isotypes in vaginal secretions (15,31,37). Cassone et al (8) showed, however, that antibodies, apparently against mannan and secretory aspartyl proteinases of C. albicans, mediated protection against infection in ovariectomized and estrogen-treated rats.…”

mentioning

confidence: 99%

A Vaccine and Monoclonal Antibodies That Enhance Mouse Resistance toCandida albicansVaginal Infection

1998

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We previously reported that a vaccine composed of liposome-mannan complexes of Candida albicans (L-mann) stimulates mice to produce protective antibodies against disseminated candidiasis. An immunoglobulin M (IgM) monoclonal antibody (MAb), B6.1, specific for a β-1,2-mannotriose in the complexes protects against the disease, whereas MAb B6 does not. In the present study, the vaccine and MAbs B6.1 and B6 were tested for the ability to protect againstCandida vaginal infection, established by intravaginal (i.vg.) inoculation of yeast cells in mice maintained in pseudoestrus. Fungal CFU in each vagina was determined to assess the severity of infection. Mice vaccinated before infection developed about 62% fewer vaginal CFU than nonimmunized controls. Naive mice that received polyclonal antiserum (from vaccinated mice) i.vg. before infection had 60% fewer CFU than controls. The serum protective factor was stable at 56°C, but C. albicans cells absorbed this factor. Mice given MAb B6.1 i.vg. after infection was established had fewerCandida CFU in vaginal tissue than control mice given buffer instead of antibody. MAbs B6.1 and B6 given intraperitoneally before infection protected mice, but MAbs preabsorbed with yeast cells did not. MAb B6.1 also protected against C. tropicalisvaginal infection, but MAb B6 did not. The protective activities of MAbs B6.1 and B6 appeared to be specific because an irrelevant IgM carbohydrate-specific MAb and an irrelevant IgG protein-specific MAb were not protective; also, MAb B6.1 did not affect development of vaginal chlamydial infection. These studies show that an appropriate antibody response, or administration of protective antibodies, can help the host to resist Candida vaginal infection.

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An immunodominant antigen of Candida albicans shows homology to the enzyme enolase

Franklyn

Warmington

Ott

et al. 1990

Immunology & Cell Biology

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ACandida‐specific antibody in patients with vaginitis

Cited by 6 publications

References 5 publications

Production and function of cytokines in natural and acquired immunity to Candida albicans infection.

Production and function of cytokines in natural and acquired immunity to Candida albicans infection.

A Vaccine and Monoclonal Antibodies That Enhance Mouse Resistance toCandida albicansVaginal Infection

An immunodominant antigen of Candida albicans shows homology to the enzyme enolase

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