This paper aims to analyze the process of deindustrialization of the Brazilian economy from a regional perspective. Since the mid-2000s there has been an intense debate about the process of deindustrialization in the Brazilian economy, obtaining significant advances in the causes, consequences and, especially, the emphasis given to the role of industry in the development of Brazil. However, the deindustrialization in the Brazilian economy is treated in a homogeneous way, so that the discussion in the regional perspective is practically disregarded. This paper attempts to reduce this debate gap in the sense that it develops concepts appropriate to the regional space and explains its causes.