A Japanese prospective multi-institutional feasibility study on accelerated partial breast irradiation using multicatheter interstitial brachytherapy: clinical results with a median follow-up of 60 months

Yoshida, Ken; Nose, Takayuki; Otani, Yuki; Asahi, Shuuji; Tsukiyama, Iwao; Dokiya, Takushi; Sendo, Toshiaki; Fukuda, Ichirou; Shinmoto, Hiroshi; Kumazaki, Yu; Takahashi, Tsuyoshi; Kotsuma, Tadayuki; Masuda, Norikazu; Yoden, Eisaku; Nakashima, Kenichiro; Matsumura, Taisei; Nakagawa, Shino; Tachiiri, Seiji; Moriguchi, Yoshio; Itami, Jun; Oguchi, Masahiko

doi:10.1007/s12282-022-01339-z

Cited by 7 publications

(1 citation statement)

References 22 publications

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“…APBI delivered with multicatheter brachytherapy permit better dose distribution with favorable dose concentration and without excessive exposure of normal tissue even in the small breasts. The 5-year results of a multi-institutional prospective study of APBI with multicatheter brachytherapy for Japanese patients were published [25]. There were no reports of Grade 4 late toxicity, local recurrence, or breast cancer-related deaths.…”

Section: Discussionmentioning

confidence: 99%

Prospective study of once-daily accelerated partial breast irradiation using 3-dimensional conformal external beam radiotherapy for Japanese women: 12-year outcomes, toxicity, and cosmesis

Takahashi,

Kagami,

Yoshimura

et al. 2024

Preprint

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Background To analyze in a prospective study the long-term safety and efficacy of 3-dimensional conformal radiotherapy (3D-CRT) to deliver accelerated partial breast irradiation (APBI) for Japanese women with early breast cancer. Methods Breast cancer patients with pathological tumor size ≤ 3 cm, age ≥ 20 years, lumpectomy with at least a 5 mm margin, and ≤ 3 positive axillary nodes were eligible. APBI was delivered by 3D-CRT at a dose of 38.5 Gy in 10 fractions over 10 days. The primary endpoints were the frequency and severity of acute and late radiation toxicities, and secondary endpoints were local control, survival, and cosmesis. The sample size was determined based on the incidence of ≥ grade 3 acute and late radiation toxicities, which required 71 enrollments. Results Between 2008 and 2010, 73 patients enrolled in this trial. Twelve patients (16%) had 1–3 lymph node metastases. At a median follow-up of 12.6 years (range: 2.7–13.9 years), there were no cases of grade ≥ 3 acute or late toxicity. There were 4 ipsilateral breast tumor recurrence (IBTR) events: 12-year IBTR incidence was 4.4%. The difference in the incidence of IBTR between node-negative and node-positive patients was marginal (1.9% vs. 16.7%, p = 0.055). The majority of patients (95.8%) had excellent/good cosmesis. Conclusions APBI delivered with 3D-CRT is a feasible treatment option for Asian females, but it was indicated that node-positive status might increase IBTR risk.

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Section: Discussionmentioning

confidence: 99%

Prospective study of once-daily accelerated partial breast irradiation using 3-dimensional conformal external beam radiotherapy for Japanese women: 12-year outcomes, toxicity, and cosmesis

Takahashi,

Kagami,

Yoshimura

et al. 2024

Preprint

Self Cite

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Feasibility of accelerated partial breast irradiation with strut-adjusted volume implant brachytherapy in Japan focusing on dosimetry and acute toxicity: a Japanese multi-institutional prospective study

Yoshida,

Yoshimura,

Notake

et al. 2023

Breast Cancer

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Prospective study of once-daily accelerated partial breast irradiation using 3-dimensional conformal external beam radiotherapy for Japanese women: 12-year outcomes, toxicity, and cosmesis

Takahashi,

Kagami,

Yoshimura

et al. 2024

Breast Cancer

View full text Add to dashboard Cite

Background To analyze in a prospective study the long-term safety and efficacy of 3-dimensional conformal radiotherapy (3D-CRT) to deliver accelerated partial breast irradiation (APBI) for Japanese women with early breast cancer. Methods Breast cancer patients with pathological tumor size ≤ 3 cm, age ≥ 20 years, lumpectomy with at least a 5 mm margin, and ≤ 3 positive axillary nodes were eligible. APBI was delivered by 3D-CRT at a dose of 38.5 Gy in 10 fractions over 10 days. The primary endpoints were the frequency and severity of acute and late radiation toxicities, and secondary endpoints were local control, survival, and cosmesis. The sample size was determined based on the incidence of ≥ grade 3 acute and late radiation toxicities, which required 71 enrollments. Results Between 2008 and 2010, 73 patients enrolled in this trial. Twelve patients (16%) had 1–3 lymph node metastases. At a median follow-up of 12.6 years (range: 2.7–13.9 years), there were no cases of grade ≥ 3 acute or late toxicity. There were 4 ipsilateral breast tumor recurrence (IBTR) events: 12-year IBTR incidence was 4.4%. The difference in the incidence of IBTR between node-negative and node-positive patients was marginal (1.9% vs. 16.7%, p = 0.055). The majority of patients (94.4% at 2 years, 89.3% at 10 years after enrollment) had excellent/good cosmesis. Conclusions APBI delivered with 3D-CRT is a feasible treatment option for Asian females, but it was indicated that node-positive status might increase IBTR risk.

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A Japanese prospective multi-institutional feasibility study on accelerated partial breast irradiation using multicatheter interstitial brachytherapy: clinical results with a median follow-up of 60 months

Cited by 7 publications

References 22 publications

Prospective study of once-daily accelerated partial breast irradiation using 3-dimensional conformal external beam radiotherapy for Japanese women: 12-year outcomes, toxicity, and cosmesis

Prospective study of once-daily accelerated partial breast irradiation using 3-dimensional conformal external beam radiotherapy for Japanese women: 12-year outcomes, toxicity, and cosmesis

Feasibility of accelerated partial breast irradiation with strut-adjusted volume implant brachytherapy in Japan focusing on dosimetry and acute toxicity: a Japanese multi-institutional prospective study

Prospective study of once-daily accelerated partial breast irradiation using 3-dimensional conformal external beam radiotherapy for Japanese women: 12-year outcomes, toxicity, and cosmesis

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