With the explosion of the generation, transmission and sharing of image data over the Internet and other unsecured networks, the need for and significance of the development of novel image encryption algorithms are unprecedented. In this research work, we propose a novel framework for image encryption that is based on two hyperchaotic maps utilized in conjunction with the single neuron model (SNM). The framework entails three successive stages, where in every stage a substitution box (S-box) is applied, then XORing with an encryption key is carried out. The S-boxes and the encryption keys are generated from the numerical solutions of the hyperchaotic maps and the SNM. The performance of the proposed framework is gauged through a number of metrics, reflecting superior performance and complete asymmetry between the plain images and their encrypted versions. The main advantages of this work are (1) vast key space and (2) high encryption efficiency. The superior key space of 22551 is the result of employing the two hyperchaotic maps, while the improved efficiency, resulting in an average encryption rate of 8.54 Mbps, is the result of using the SNM as well as the employment of optimized parallel processing techniques. In addition, the proposed encryption framework is shown to output encrypted images that pass the NIST SP 800 suite. Average achieved values for the metrics include MSE of 9626, PSNR of 8.3 dB, MAE of 80.99, entropy of 7.999, NPCR of 99.6% and UACI of 31.49%.