A key role for Abl family kinases in EphA receptor-mediated growth cone collapse

Harbott, Lene K.; Nobes, Catherine D.

doi:10.1016/j.mcn.2005.05.002

Cited by 42 publications

(34 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, altered epithelial morphology and stratification in the mutant GT vasculature is more likely to reflect a change in key matrix or cytoskeletal components. These factors are necessary for a tissue-specific morphological state, and it has been recently demonstrated that they are regulated by Eph-ephrin signaling (reviewed by Cheng et al, 2002;Harbott and Nobes, 2005;Hunter et al, 2006;Marston and Goldstein, 2006).…”

Section: Discussionmentioning

confidence: 99%

HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia

Shaut¹,

Saneyoshi²,

Morgan³

et al. 2007

Developmental Dynamics

View full text Add to dashboard Cite

Hypospadias, a common defect affecting the growth and closure of the external genitalia, is often accompanied by gross enlargements of the genital tubercle (GT) vasculature. Because Hoxa13 homozygous mutant mice also exhibit hypospadias and GT vessel expansion, we examined whether genes playing a role in angiogenesis exhibit reduced expression in the GT. From this analysis, reductions in EphA6 and EphA7 were detected. Characterization of EphA6 and EphA7 expression in the GT confirmed colocalization with HOXA13 in the GT vascular endothelia. Analysis of the EphA6 and EphA7 promoter regions revealed a series of highly conserved cis-regulatory elements bound by HOXA13 with high affinity. GT chromatin immunoprecipitation confirmed that HOXA13 binds these gene-regulatory elements in vivo. In vitro, HOXA13 activates gene expression through the EphA6 and EphA7 gene-regulatory elements. Together these findings indicate that HOXA13 directly regulates EphA6 and EphA7 in the developing GT and identifies the GT vascular endothelia as a novel site for HOXA13-dependent expression of EphA6 and EphA7. Developmental Dynamics 236:951-960, 2007.

show abstract

Section: Discussionmentioning

confidence: 99%

HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia

Shaut¹,

Saneyoshi²,

Morgan³

et al. 2007

Developmental Dynamics

View full text Add to dashboard Cite

show abstract

“…This phosphorylation is required for the planar polarized distribution of β-catenin prior to rosette formation. The upstream activator of Abl has not been identified in the context of Drosophila axis elongation, although Abl is regulated by EGF (Hopkins et al, 2012), platelet-derived growth factor (PDGF) (Brasher and Van Etten, 2000), EphA (Harbott and Nobes, 2005) and Robo (Rhee et al, 2002) in other contexts. Thus, these extracellular cues are prime candidates for activators of Abl, and hence rosette formation, during epithelial morphogenesis in Drosophila.…”

Section: Drosophila Epithelial Morphogenesismentioning

confidence: 99%

The roles and regulation of multicellular rosette structures during morphogenesis

2014

View full text Add to dashboard Cite

Multicellular rosettes have recently been appreciated as important cellular intermediates that are observed during the formation of diverse organ systems. These rosettes are polarized, transient epithelial structures that sometimes recapitulate the form of the adult organ. Rosette formation has been studied in various developmental contexts, such as in the zebrafish lateral line primordium, the vertebrate pancreas, the Drosophila epithelium and retina, as well as in the adult neural stem cell niche. These studies have revealed that the cytoskeletal rearrangements responsible for rosette formation appear to be conserved. By contrast, the extracellular cues that trigger these rearrangements in vivo are less well understood and are more diverse. Here, we review recent studies of the genetic regulation and cellular transitions involved in rosette formation. We discuss and compare specific models for rosette formation and highlight outstanding questions in the field.

show abstract

“…Indeed, a recent study indicates that dAbl can modulate myosin-II activity to protect against improper targeting (Dorsten et al, 2007). However, pharmacological inhibition of both Abl and Arg blocks ephrin-A5-mediated growthcone collapse, a process that is known to depend on Rho signaling through ROCK (Harbott and Nobes, 2005). Thus, in contrast to the loss of Arg function in fibroblasts, which elevates Rho activity, loss of both Abl and Arg function might compromise Rho signaling in growth cones.…”

Section: Journal Of Cell Science 122 (19)mentioning

confidence: 99%

Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts

Bradley

Koleske

2009

Journal of Cell Science

159

206

View full text Add to dashboard Cite

The Abl-family non-receptor tyrosine kinases are essential regulators of the cytoskeleton. They transduce diverse extracellular cues into cytoskeletal rearrangements that have dramatic effects on cell motility and morphogenesis. Recent biochemical and genetic studies have revealed several mechanisms that Abl-family kinases use to mediate these effects. Abl-family kinases stimulate actin polymerization through the activation of cortactin, hematopoietic lineage cell-specific protein (HS1), WASp-and WAVE-family proteins, and Rac1. They also attenuate cell contractility by inhibiting RhoA and altering adhesion dynamics. These pathways impinge on several physiological processes, including development and maintenance of the nervous and immune systems, and epithelial morphogenesis. Elucidating how Abl-family kinases are regulated, and where and when they coordinate cytoskeletal changes, is essential for garnering a better understanding of these complex processes.

show abstract

A key role for Abl family kinases in EphA receptor-mediated growth cone collapse

Cited by 42 publications

References 66 publications

HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia

HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia

The roles and regulation of multicellular rosette structures during morphogenesis

Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts

Contact Info

Product

Resources

About