A-Kinase Anchoring Protein 150 and Protein Kinase A Complex in the Basolateral Amygdala Contributes to Depressive-like Behaviors Induced by Chronic Restraint Stress

Repeated vagus nerve stimulation produces anxiolytic effects via upregulation of AMPAR function in centrolateral amygdala of male rats

“…There is several evidence that alteration of neuronal activity is a form of neuroplasticity ( Samson and Pare, 2005 ) and synaptic recruitment of AMPARs plays a crucial role in activity-dependent synaptic plasticity ( Zhou et al, 2019 ). AMPARs are ionotropic glutamate receptors that mediate majority of the fast-excitatory neurotransmission in the brain.…”

“…Tissue preparation and western blotting were performed according to our previous study ( Zhou et al, 2019 ). The CeL slices from two rats were rinsed with ice-cold ACSF and then incubated with ACSF containing 1.0 mg/ml sulfo–NHS–LC-biotin (Thermo Fisher Scientific, Rockford, USA) for 90 min at 4 °C with gentle shaking.…”

Downregulation of surface AMPA receptor expression in the striatum following prolonged social isolation, a role of mGlu5 receptors

“…Neonatal social isolation prevented experience-dependent synaptic trafficking of AMPA receptors in the rat barrel cortex ( Miyazaki et al, 2012 , Miyazaki et al, 2013 ) and medial PFC ( Tada et al, 2016 ). It appears that expression of AMPA receptors in the PFC and hippocampus is generally downregulated in depressed animals, although chronic social isolation for 4 weeks upregulated GluA1 and GluA2 protein levels in the mouse amygdala ( Shimizu et al, 2016 ) and chronic restraint stress elevated surface GluA1 but not GluA2 expression in the mouse basolateral amygdala ( Zhou et al, 2019 ).…”

Research progress on classical traditional chinese medicine formula xiaoyaosan in the treatment of depression

“…Studies have shown that AMPA receptors, as ionotropic glutamate receptors, are important in both synaptic plasticity and cell death caused by neurological disease and dysfunction ( Whitehead et al, 2017 ). AMPA receptors can participate in the pathogenesis of depression by changing synaptic plasticity, and directly or indirectly participate in the mechanism of depression as antidepressants ( Aleksandrova et al, 2017 ; Zhou et al, 2019 ). Liang et al found that chronic immobilization stress (CIS) induced a decrease in GluR2 mRNA and an increase in GluR1 mRNA in the hippocampal CA1 area of rats; ultrastructural damage was also observed in this region.…”