A kind of smart gold nanoparticle–hydrogel composite with tunable thermo-switchable electrical properties

Zhao, Xiuli; Ding, Xiaobin; Deng, Zhenghua; Zheng, Zhaohui; Peng, Yuxing; Tian, Chen; Long, Xinping

doi:10.1039/b601069e

Cited by 54 publications

(55 citation statements)

References 30 publications

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“…45, 105 Compared to physically embedding, covalent link allows for using various hydrogel responsiveness to modulate inter-particle distances, hence offering precise control of nanoscale interactions through bulk templates. 115 Meanwhile, when nanoparticles are covalently linked, they form the nodes of the polymer network and reduce the relaxation length of hydrogel scaffolds, leading to significantly enhanced bulk response to environment stimuli. 9 Permanent linkage to the network also prevents nanoparticles from diffusing out of the gel, thereby limiting the loss of responsive materials and the potential toxic effects in biomedical applications.…”

Section: Stimuli-responsive Drug Deliverymentioning

confidence: 99%

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

et al. 2016

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Nanoparticles have offered a unique set of properties for drug delivery including high drug loading capacity, combinatorial delivery, controlled and sustained drug release, prolonged stability and lifetime, and targeted delivery. To further enhance therapeutic index, especially for localized application, nanoparticles have been increasingly combined with hydrogels to form a hybrid biomaterial system for controlled drug delivery. Herein, we review recent progresses in engineering such nanoparticle-hydrogel hybrid system (namely ‘NP-gel’) with a particular focus on its application for localized drug delivery. Specifically, we highlight four research areas where NP-gel has shown great promises, including (1) passively controlled drug release, (2) stimuli-responsive drug delivery, (3) site-specific drug delivery, and (4) detoxification. Overall, integrating therapeutic nanoparticles with hydrogel technologies creates a unique and robust hybrid biomaterial system that enables effective localized drug delivery.

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Section: Stimuli-responsive Drug Deliverymentioning

confidence: 99%

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

et al. 2016

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“…In fact, embedding inorganic nanoparticles or nanosheets into polymer matrices has proved to be an effective method of enhancing the functionality of the material. 15 Such hybrid hydrogels are reported to have useful mechanical, optical, or magnetic properties. 16,17 Harada et al 18 prepared hybride hydrogel through CD-functionalized carbon nanotube.…”

Section: Introductionmentioning

confidence: 99%

Dual Stimuli-Responsive Supramolecular Hydrogel Based on Hybrid Inclusion Complex (HIC)

et al. 2010

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A novel dual-responsive supramolecular hydrogel composed of an azobenzene (AZO) endfunctionalized block copolymer PDMA-b-PNIPAM (AZO-(PDMA-b-PNIPAM)) and β-cyclodextrin-modified CdS quantum dot (β-CD@QD) has been demonstrated. Based on the host-guest inclusion complexation of AZO of the block copolymers and CD cavities on β-CD@QD, they form a hybrid inclusion complex (HIC). The HIC contains a QD as the core and the block copolymer as the shell with the PNIPAM block as the outer layer. Dynamic light scattering (DLS) and UV-vis spectroscopy investigation proved the HIC structure in diluted solution. Hydrogel formed easily upon heating the aqueous solution of HIC at a concentration as low as 7 wt %; as a result of PNIPAM, aggregation occurred above the LCST. The inclusion complex and the domains of the collapsed PNIPAM chains serve as two distinct cross-links and render the hydrogel excellent dual sensitivity to competitive hosts/guests substitution and to temperature variation. Furthermore, rheology results quantitatively exhibit the hydrogel formation mechanism and the sol-to-gel reversibility following the two external stimuli.

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“…These thermally responsive polymer-metal NP composites have been investigated for cancer therapy by combining the metal NP ability to generate heat with polymeric drug delivery. 12,19,28,37,47,90,106,107 Thus, the composite polymeric NPs can be irradiated with light, causing the metal NPs to generate heat, in turn resulting in polymer phase changes that can facilitate chemotherapy by drug release.…”

Section: Polymeric Nanoparticle Compositesmentioning

confidence: 99%

Tunable Nanostructures as Photothermal Theranostic Agents

2011

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The theranostic potential of several nanostructures has been discussed in the context of photothermal therapies and imaging. In the last several decades, the burden of cancer has grown rapidly, making the need for new theranostic approaches vital. Lasers have emerged as promising tools in cancer treatment, especially with the advent of photothermal therapies wherein light absorbing dyes or plasmonic gold nanoparticles are used to generate heat and achieve tumor damage. Recently, photoabsorbing nanostructures have materialized that can be employed in conjunction with lasers in the near-infrared region in order to enhance both imaging and photothermal effects. The incorporation of tunable nanostructures has resulted in improved specificity in cancer treatment. Silica-cored gold nanoshells and gold nanorods currently serve as the chief plasmonic structures for photothermal therapy. Although gold nanorods and silica-cored gold nanoshells have shown promise as therapeutic agents, over the past few years new nanostructures have emerged that offer comparable and even superior theranostic properties. In the present review, several theranostic agents and their impact on the development of more effective photothermal therapies for the treatment of cancer are discussed. These agents include hollow gold nanoshells, gold gold-sulfide nanoparticles, gold nanocages, carbon and titanium nanotubes, photothermal-based nanobubbles, polymeric nanoparticles and copper-based nanocrystals.

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A kind of smart gold nanoparticle–hydrogel composite with tunable thermo-switchable electrical properties

Cited by 54 publications

References 30 publications

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery

Dual Stimuli-Responsive Supramolecular Hydrogel Based on Hybrid Inclusion Complex (HIC)

Tunable Nanostructures as Photothermal Theranostic Agents

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