1964
DOI: 10.1021/bi00898a019
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A Kinetic Investigation of the Interaction of Adenosine-5'-triphosphate with Divalent Metal Ions*

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Cited by 39 publications
(14 citation statements)
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“…I n the reverse direction, random binding of ADP and M++ may occur, since ADP,rather than ADP .Mg-, competes with ATP .Mg' [l]. The efficiencies of the ions as activators do not correlate with the stability constants of ATP-M= complexes [lo], the rate constants of their formation and dissociation [25], the acidity of the ions or the atomic radii. The determining parameter may therefore be the ability of each ion to €orm a ternary 18 European J.…”
Section: Discussionmentioning
confidence: 99%
“…I n the reverse direction, random binding of ADP and M++ may occur, since ADP,rather than ADP .Mg-, competes with ATP .Mg' [l]. The efficiencies of the ions as activators do not correlate with the stability constants of ATP-M= complexes [lo], the rate constants of their formation and dissociation [25], the acidity of the ions or the atomic radii. The determining parameter may therefore be the ability of each ion to €orm a ternary 18 European J.…”
Section: Discussionmentioning
confidence: 99%
“…We calculated the final free magnesium concentration in each case, using the stability constant for binding of magnesium to the unprotonated form of ADP (9,10). Furthermore, because the kinetics of equilibration of this reaction is extremely rapid (11,12), particularly relative to the dead time of the stopped flow (1.3 ms), we assumed that the final concentrations of magnesium were formed by the end of the mixing phase. The dissociation of 2ЈdmD from myosin V was monitored by energy transfer from vicinal tryptophan and tyrosine residues, as reported in our earlier studies (5).…”
Section: Effect Of Magnesium On the Kinetics Of Adp Release From Andmentioning
confidence: 99%
“…The interaction of bivalent cations with phosphates and other ligands has been examined in detail by Hammes and his co-workers. The binding of Mg2+ to phosphate occurs in two steps (Hammes & Levison, 1964); the first is the formation of an ion-pair, and the second is the loss of one or more molecules of water from the first hydration shell of the cation to produce the complex. The second step is rate-limiting, and thus the rate of formation of magnesium complexes of this type is independent of the nature of the ligand.…”
Section: Preparationmentioning
confidence: 99%