2022
DOI: 10.1038/s41598-022-07306-0
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A Lab-in-a-Fiber optofluidic device using droplet microfluidics and laser-induced fluorescence for virus detection

Abstract: Microfluidics has emerged rapidly over the past 20 years and has been investigated for a variety of applications from life sciences to environmental monitoring. Although continuous-flow microfluidics is ubiquitous, segmented-flow or droplet microfluidics offers several attractive features. Droplets can be independently manipulated and analyzed with very high throughput. Typically, microfluidics is carried out within planar networks of microchannels, namely, microfluidic chips. We propose that fibers offer an i… Show more

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Cited by 26 publications
(20 citation statements)
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“…Optofluidic sensor platforms are being intensely studied for their unique combination of optical precision and sensitivity and lab-on-a-chip ease-of-use and efficiency [1][2][3]. Many recently reported optofluidic devices exploit the straight-forward integration of optical components (light emitting diodes, lenses, optical filters) and fluidics (microfluidic channels, capillaries, droplets) [4][5][6]. However, some of the most promising optical and fluidic phenomena are not easily integrated, due to incompatibility of physical or chemical constraints, and, when achieved, are anchored to the laboratory by the necessary infrastructure [7].…”
Section: Introductionmentioning
confidence: 99%
“…Optofluidic sensor platforms are being intensely studied for their unique combination of optical precision and sensitivity and lab-on-a-chip ease-of-use and efficiency [1][2][3]. Many recently reported optofluidic devices exploit the straight-forward integration of optical components (light emitting diodes, lenses, optical filters) and fluidics (microfluidic channels, capillaries, droplets) [4][5][6]. However, some of the most promising optical and fluidic phenomena are not easily integrated, due to incompatibility of physical or chemical constraints, and, when achieved, are anchored to the laboratory by the necessary infrastructure [7].…”
Section: Introductionmentioning
confidence: 99%
“…Salmonella at the single-cell level could be specifically detected by employing a novel microdroplet approach [ 176 ]. In addition to these, microfluidic droplet technology has the potential to do surveillance for infectious pathogens such as bacterial in fresh-cut wash water [ 177 ], a virus such as SARS-CoV-2 [ 178 ], and automated detection and monitoring of chemical and biological warfare agents [ 179 ].…”
Section: New Perspectives and Emerging Pathogenic Detection Devicesmentioning
confidence: 99%
“…Highly sensitive and accurate novel liquid flow sensors and their corresponding detection methods are pivotal to the systemic performance. Until now, traditional detection methods, such as electrochemical, [ 7–9 ] mass spectrometry, [ 10–12 ] and laser‐induced fluorescence detection [ 13–15 ] are limited in application due to their complex structure, high cost, bulky size, and the generation of pollutants, which seriously restrict their sensitivity and portability. The recently emerged optofluidics, which refers to the integration of photonics with fluidics at the chip scale, has attracted extensive attentions due to its simplistic reagents, integration excellence, and miniaturization.…”
Section: Introductionmentioning
confidence: 99%