A lab-on-chip platform for simultaneous culture and electrochemical detection of bacteria

Srikanth, Sangam; S, Jayapiriya U.; Dubey, Satish Kumar; Javed, Arshad; Goel, Sanket

doi:10.1016/j.isci.2022.105388

Cited by 17 publications

(8 citation statements)

References 31 publications

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“…In addition, cyclic voltammetry has been applied for the quantitative analysis of samples. For example, Srikanth et al developed a microfluidic platform without any biological modification of the electrodes and used CV to study the variation of bacteria concentrations overtime [ 84 ]. For integration with DMF, K.C.…”

Section: Integrated Microfluidic Systemsmentioning

confidence: 99%

Advances in Integration, Wearable Applications, and Artificial Intelligence of Biomedical Microfluidics Systems

Guo

et al. 2023

Micromachines

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Microfluidics attracts much attention due to its multiple advantages such as high throughput, rapid analysis, low sample volume, and high sensitivity. Microfluidics has profoundly influenced many fields including chemistry, biology, medicine, information technology, and other disciplines. However, some stumbling stones (miniaturization, integration, and intelligence) strain the development of industrialization and commercialization of microchips. The miniaturization of microfluidics means fewer samples and reagents, shorter times to results, and less footprint space consumption, enabling a high throughput and parallelism of sample analysis. Additionally, micro-size channels tend to produce laminar flow, which probably permits some creative applications that are not accessible to traditional fluid-processing platforms. The reasonable integration of biomedical/physical biosensors, semiconductor microelectronics, communications, and other cutting-edge technologies should greatly expand the applications of current microfluidic devices and help develop the next generation of lab-on-a-chip (LOC). At the same time, the evolution of artificial intelligence also gives another strong impetus to the rapid development of microfluidics. Biomedical applications based on microfluidics normally bring a large amount of complex data, so it is a big challenge for researchers and technicians to analyze those huge and complicated data accurately and quickly. To address this problem, machine learning is viewed as an indispensable and powerful tool in processing the data collected from micro-devices. In this review, we mainly focus on discussing the integration, miniaturization, portability, and intelligence of microfluidics technology.

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Section: Integrated Microfluidic Systemsmentioning

confidence: 99%

Advances in Integration, Wearable Applications, and Artificial Intelligence of Biomedical Microfluidics Systems

Guo

et al. 2023

Micromachines

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“…In combination with the working principles of microfluidics, these devices show potential in health applications, medicine, and more. The designs and applications go in various directions—for example, injection-molded polymeric LOC for blood plasma separation [ 1 ], plastic LOC for herbicide residue monitoring in soil [ 2 ], and devices for the detection of various pathogens in food [ 3 , 4 ], for the detection of viruses [ 5 , 6 ], and for the detection of bacteria [ 7 ]. The applications of LOC devices do not end here; they could be used for research on various cells, such as research on the growth of fungal cultures [ 8 ] or on cancer and tumor cells [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Combined Femtosecond Laser Glass Microprocessing for Liver-on-Chip Device Fabrication

Butkutė

Jurkšas²,

Baravykas³

et al. 2023

Materials

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Nowadays, lab-on-chip (LOC) devices are attracting more and more attention since they show vast prospects for various biomedical applications. Usually, an LOC is a small device that serves a single laboratory function. LOCs show massive potential for organ-on-chip (OOC) device manufacturing since they could allow for research on the avoidance of various diseases or the avoidance of drug testing on animals or humans. However, this technology is still under development. The dominant technique for the fabrication of such devices is molding, which is very attractive and efficient for mass production, but has many drawbacks for prototyping. This article suggests a femtosecond laser microprocessing technique for the prototyping of an OOC-type device—a liver-on-chip. We demonstrate the production of liver-on-chip devices out of glass by using femtosecond laser-based selective laser etching (SLE) and laser welding techniques. The fabricated device was tested with HepG2(GS) liver cancer cells. During the test, HepG2(GS) cells proliferated in the chip, thus showing the potential of the suggested technique for further OOC development.

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“…Different analytical technologies have been exploited to develop these analytical and bioanalytical devices such as chromatography, [6][7][8] spectroscopy, [9][10][11][12][13][14][15][16][17][18][19] electrophoresis, [20][21][22][23][24][25][26][27] immunoassay, [28][29][30][31][32][33][34][35] and electrochemistry. [36][37][38][39][40][41] However, accurate and selective determination of such microorganisms is usually performed by coupling different analytical methodologies to achieve the optimum analysis. For instance, several POC diagnostic biosensors are based on using electrochemical systems for sensing the pathogens using immunoassay techniques for accurate and specific analysis.…”

Section: Introductionmentioning

confidence: 99%

Advances in miniaturized nanosensing platforms for analysis of pathogenic bacteria and viruses

Zeid,

Mostafa,

Lou

et al. 2023

Lab Chip

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A lab-on-chip platform for simultaneous culture and electrochemical detection of bacteria

Cited by 17 publications

References 31 publications

Advances in Integration, Wearable Applications, and Artificial Intelligence of Biomedical Microfluidics Systems

Advances in Integration, Wearable Applications, and Artificial Intelligence of Biomedical Microfluidics Systems

Combined Femtosecond Laser Glass Microprocessing for Liver-on-Chip Device Fabrication

Advances in miniaturized nanosensing platforms for analysis of pathogenic bacteria and viruses

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