Advances in miniaturized nanosensing platforms for analysis of pathogenic bacteria and viruses

Abstract

Integration of smart miniaturized nanosensors with artificial intelligence results in precise detection of pathogenic bacteria or viruses in biological samples.

Enzyme-free electrochemical sensor platforms based on transition metal nanostructures for clinical diagnostics

“…The growing trend of the construction of miniaturized sensors based on transition metal nanostructures is exceptional due to the increasing demand in clinical and biomedical sectors. 88–90 Specifically, the amperometric-derived miniaturized biosensors deal with numerous merits, including the ease of instrument handling, quick response, great sensitivity, selectivity, and positively engagement for the on-time monitoring of glucose biomarkers when compared to other detection strategies. The detection of glucose is crucial in clinical diagnostics.…”

Disposable capillary-fill device for the determination of proteases incorporating elimination of light-shielding from the magnetic beads with cleavage of the electrogenerated chemiluminescence label-tagged peptide probe

“…Point-of-care testing (POCT), which involves real-time analysis near or at the site of patient specimen collection, has widespread applications in the fields of healthcare diagnostics and environmental monitoring 1,2 due to its excellent convenience, cost-effectiveness, specificity, accuracy, portability and low operation requirements. 3–5 Generally, emergent POCT systems use various biosensing methods with optical and electrochemical readouts to provide quantitative results, 3,6 such as electrochemistry, 7 colorimetry, 8 electrogenerated chemiluminescence (ECL), 3,9,10 surface-enhanced Raman scattering, 11 fluorescence (FL), 12 etc . Among them, ECL is an ideal approach for POCT because of its advantages of high sensitivity at low concentrations, high spatiotemporal controllability, and the fact that it does not require an external light source.…”