A label-free fiber-optic Turbidity Affinity Sensor (TAS) for continuous glucose monitoring

Dutt-Ballerstadt, Ralph; Evans, Colton; Pillai, Arun P.; Gowda, Ashok

doi:10.1016/j.bios.2014.05.034

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…The detection principle of the sensors generally requires that analytes in a solution interact with receptor molecules. These are often immobilized onto a sensor surface, although other sensor principles that, for example, rely on a volume-related detection have also been developed [ 2 , 3 ]. In this review, we focus on surface-based biosensors, however.…”

Section: Introductionmentioning

confidence: 99%

Dielectrophoresis: An Approach to Increase Sensitivity, Reduce Response Time and to Suppress Nonspecific Binding in Biosensors?

2022

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The performance of receptor-based biosensors is often limited by either diffusion of the analyte causing unreasonable long assay times or a lack of specificity limiting the sensitivity due to the noise of nonspecific binding. Alternating current (AC) electrokinetics and its effect on biosensing is an increasing field of research dedicated to address this issue and can improve mass transfer of the analyte by electrothermal effects, electroosmosis, or dielectrophoresis (DEP). Accordingly, several works have shown improved sensitivity and lowered assay times by order of magnitude thanks to the improved mass transfer with these techniques. To realize high sensitivity in real samples with realistic sample matrix avoiding nonspecific binding is critical and the improved mass transfer should ideally be specific to the target analyte. In this paper we cover recent approaches to combine biosensors with DEP, which is the AC kinetic approach with the highest selectivity. We conclude that while associated with many challenges, for several applications the approach could be beneficial, especially if more work is dedicated to minimizing nonspecific bindings, for which DEP offers interesting perspectives.

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Section: Introductionmentioning

confidence: 99%

Dielectrophoresis: An Approach to Increase Sensitivity, Reduce Response Time and to Suppress Nonspecific Binding in Biosensors?

2022

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“…Continuous monitoring has been applied in numerous fields such as clinical diagnosis [1], water quality control [2], pharmaceutical product quality control [3] and also corrosion quality control [4], as it allows instantaneous measurement of the sample. Fiber optic [1] and colorimetric analysis [2] have been used in in vitro monitoring of glucose for 125 minutes and ultra-trace lead for 80 minutes, while [3]- [6] employed an electrochemical technique to in vitro and in situ monitoring of ions hydroxyl for 45 minutes, chloride for 60 seconds and ferricyanide for 2 and 15 minutes, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…Fiber optic [1] and colorimetric analysis [2] have been used in in vitro monitoring of glucose for 125 minutes and ultra-trace lead for 80 minutes, while [3]- [6] employed an electrochemical technique to in vitro and in situ monitoring of ions hydroxyl for 45 minutes, chloride for 60 seconds and ferricyanide for 2 and 15 minutes, respectively. The electrochemical technique is very popular due to its specificity, cost effectiveness, user friendliness, portability and its ability to furnish continuous real time signals [4] compared to the expensive fiber optic assays and limitations of the visual method in colorimetric analysis.…”

Section: Introductionmentioning

confidence: 99%

Integration of electrochemical detection into micropumps for continuous monitoring system

Noi

Chee

Harun

et al. 2015

2015 10th Asian Control Conference (ASCC)

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This paper proposes the integration of electrochemical detection to micropumps for continuous monitoring of ferrocyanide ions. A homemade device is fabricated using 3D printing and casting techniques with a top and bottom layer of 0.5 mm and 3.0 mm, respectively. The volumetric flow and cyclic voltammetry performances of the device are evaluated at the actuator frequency of 10-50 Hz, in 10 Hz increments at concentrations of 2-10 mM, in 2 mM increments. The fabricated device exhibits maximum flow rate of 0.30405 ml/min in the reverse direction with resonance frequency of 20 Hz. The oxidation peak current at 16.02018 μA of 10 mM potassium ferrocyanide in 1 M potassium nitrate is noted. Among the various concentrations of potassium ferrocyanide, 10 mM of potassium ferrocyanide in 1 M potassium nitrate at the maximum flow rate shows the highest oxidation peak current at 16.02018 μA. The presented device offers the advantage of an affordable miniaturized bedside patient continuous monitoring system, due to its low fabrication cost. Additionally, the disposability nature of the device assures collected samples are unpolluted.

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First application of a transcutaneous optical single-port glucose monitoring device in patients with type 1 diabetes mellitus

Rumpler

Mader

Fischer³

et al. 2017

Biosensors and Bioelectronics

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A label-free fiber-optic Turbidity Affinity Sensor (TAS) for continuous glucose monitoring

Cited by 5 publications

References 18 publications

Dielectrophoresis: An Approach to Increase Sensitivity, Reduce Response Time and to Suppress Nonspecific Binding in Biosensors?

Dielectrophoresis: An Approach to Increase Sensitivity, Reduce Response Time and to Suppress Nonspecific Binding in Biosensors?

Integration of electrochemical detection into micropumps for continuous monitoring system

First application of a transcutaneous optical single-port glucose monitoring device in patients with type 1 diabetes mellitus

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