A Large Population Genetic Study of 15 Autosomal Short Tandem Repeat Loci for Establishment of Korean DNA Profile Database

Yoo, Seong Yul; Cho, Nam Soo; Park, Myung Jin; Seong, Ki Min; Hwang, Jeong Ah; Song, Seung‐Wan; Han, Myun Soo; Lee, Won Tae; Chung, Ki Wha

doi:10.1007/s10059-011-2288-4

Cited by 43 publications

(16 citation statements)

References 22 publications

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“…1). Four separate aggregates were evident in PCA plot: Indian lowlanders comprising Bhils and Tamils were placed in the upper right quadrant, Indian lowlanders comprising Brahmins, Komatis and Rajus were placed in the lower right quadrant, Gorkhas of present study were placed in the upper left quadrant along with Nepalese8, Kathmandu10, Nepal19 as well as with Korean18 and Chinese20 population. It is worthwhile to mention here that low bootstrap value between Gorkhas and Nepalese was observed in the phylogenetic tree (Fig.…”

Section: Resultsmentioning

confidence: 71%

Genetic Diversity in Gorkhas: an Autosomal STR Study

Preet

Malhotra

Shrivastava

et al. 2016

Sci Rep

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Genotyping of highly polymorphic autosomal short tandem repeat (STR) markers is a potent tool for elucidating genetic diversity. In the present study, fifteen autosomal STR markers were analyzed in unrelated healthy male Gorkha individuals (n = 98) serving in the Indian Army by using AmpFlSTR Identifiler Plus PCR Amplification Kit. In total, 138 alleles were observed with corresponding allele frequencies ranging from 0.005 to 0.469. The studied loci were in Hardy-Weinberg Equilibrium (HWE). Heterozygosity ranged from 0.602 to 0.867. The most polymorphic locus was Fibrinogen Alpha (FGA) chain which was also the most discriminating locus as expected. Neighbor Joining (NJ) tree and principal component analysis (PCA) plot clustered the Gorkhas with those of Nepal and other Tibeto-Burman population while lowlander Indian population formed separate cluster substantiating the closeness of the Gorkhas with the Tibeto-Burman linguistic phyla. Furthermore, the dataset of STR markers obtained in the study presents a valuable information source of STR DNA profiles from personnel for usage in disaster victim identification in military exigencies and adds to the Indian database of military soldiers and military hospital repository.

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Section: Resultsmentioning

confidence: 71%

Genetic Diversity in Gorkhas: an Autosomal STR Study

Preet

Malhotra

Shrivastava

et al. 2016

Sci Rep

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“…During the analysis of the samples for 15 STR loci, a total of 162 alleles were observed with allele frequencies ranging from 0.4812 (TH01) to 0.0010 (CSF1PO, D3S1358, D5S818, D7S820, D13S317, D16S539, D18S51, Table S2 shows pairwise Fst and p values for differentiation test between the Miao ethnic minority and nine published populations [6][7][8][9][10], where the statistically significant differences (p < 0.00333) were found with Japanese [11] at 12 STR loci, Korean [10] at 10 STR loci, Uyghur [9] at seven STR loci, Guangxi Hui [7] at five STR loci, Guangxi Maonan [6] at 4 STR loci, Guangxi Han [8] at three STR loci, Guangxi Yao [6] at two STR loci and Guangxi Mulao [6] at one STR locus. As expected, there was no statistically significant difference at any STR loci within Miao population (Guizhou Miao and Guangxi Miao [6]).…”

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confidence: 99%

Population data for 15 autosomal STR loci in the Miao ethnic minority from Guizhou Province, Southwest China

Zhang

2015

Forensic Science International: Genetics

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“…Assuming the consensus profile obtain from brain sample is the full profile of the mummy, the random match probability of the sample from brain is 3.3 × 10 −11 with the allele frequency data from Yoo et al, (). For the three teeth samples, allele drop‐out events were observed.…”

Section: Resultsmentioning

confidence: 99%

Joseon Funerary Texts Tested Using Ancient DNA Analysis of a Korean Mummy

Koh

Yoo

et al. 2015

The Anatomical Record

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In Korea, ancient DNA (aDNA) analysis has been applied to investigations into the genetic affiliations of mummies found in Joseon Dynasty tombs (1392( -1910, becoming now indispensable tool for researches studying human remains from archaeological sites. In the course of our recent examinations on a Korean mummy of Joseon Dynasty, we discovered many teeth contained in a pouch. And in fact, the historical literature on the topic of Joseon funerals contain general accounts of pouches in which an individual's lost teeth were collected over the course of a lifetime and, after death, placed in the coffin with the body. To test the veracity of the historical texts, the present study undertook aDNA analyses and compared the results between specifically questioned (Q) samples (teeth) and known (K) samples (brain and bone) from the mummy to ensure that they came from the same individual. Although the Q-K comparison of autosomal short tandem repeat results did not show full concordance due to allelic drop-outs in some loci, our statistical calculation indicated that the teeth in the pouch are highly likely those of the mummy. Additionally, Q-K comparison of mitochondrial DNA sequence results showed 100% matches between samples. There results, in short, Abbreviations used: aDNA 5 ancient DNA; BSA 5 bovine serum albumin;; CT 5 computed tomography; DTT 5 dithiothreitol; DVI 5 disaster victim identification; EDTA 5 ethylenediaminetetraacetic acid; HVR 5 hypervariable region; LR 5 likelihood ratio; LSMB 5 lime-soil mixture barrier; MDCT 5 multi-detector computed tomography; MPR 5 multi-planar reformat; mtDNA 5 mitochondrial DNA; PCR 5 polymerase chain reaction; SDS 5 sodium dodecyl sulfate; STR 5 short tandem repeats; VR 5 volume rendering; UV 5 ultra violet.

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A Large Population Genetic Study of 15 Autosomal Short Tandem Repeat Loci for Establishment of Korean DNA Profile Database

Cited by 43 publications

References 22 publications

Genetic Diversity in Gorkhas: an Autosomal STR Study

Genetic Diversity in Gorkhas: an Autosomal STR Study

Population data for 15 autosomal STR loci in the Miao ethnic minority from Guizhou Province, Southwest China

Joseon Funerary Texts Tested Using Ancient DNA Analysis of a Korean Mummy

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