We investigate the multifusion generalization of string-net ground states and lattice Hamiltonians, delving into their associated weak Hopf symmetries. For the multifusion string-net, the gauge symmetry manifests as a general weak Hopf algebra, leading to a reducible vacuum string label; the charge symmetry, serving as a quantum double of gauge symmetry, constitutes a connected weak Hopf algebra. This implies that the associated topological phase retains its characterization by a unitary modular tensor category (UMTC). The bulk charge symmetry can also be captured by a weak Hopf tube algebra. We offer an explicit construction of the weak Hopf tube algebra structure and thoroughly discuss its properties. The gapped boundary and domain wall models are extensively discussed, with these 1d phases characterized by unitary multifusion categories (UMFCs). We delve into the gauge and charge symmetries of these 1d phases, as well as the construction of the boundary and domain wall tube algebras. Additionally, we illustrate that the domain wall tube algebra can be regarded as a cross product of two boundary tube algebras. As an application of our model, we elucidate how to interpret the defective string-net as a restricted multifusion string-net.