A layered behavioural model of platelets

Abstract

There is great interest in the application of nanotechnology to medicine, but concerns for safety are paramount. We present a modelling technique based on CSP and B as a starting point for simulation of networks of nanorobots. The model and the simulations are central features of our proposed approach to the construction of safety cases for nanomedicine applications, and complex networks of cooperating components in general.Our work is based on a case study: the clotting behaviour of (artificial) platelets. We present a model, and discuss its analysis and uses.

Event-B Specification of a Situated Multi-Agent System: Study of a Platoon of Vehicles

“…Further work includes the study of the same platooning problem with related formalisms such as CSP B [12] to focus on the interaction protocol between the agents. It also includes the specification and verification of other properties, such as unhooking or oscillation.…”

“…Schneider et al [12] apply their framework based on CSP and B as a starting point for the simulation of a biomedicine MAS. They only focus on the clotting behaviour of artificial platelets.…”

A Transactional Architecture for Simulation

“…As more complex simulations were constructed, the lack of structure to the communications made it increasingly difficult to reason formally about the behaviour of the simulations. Model-checking is one way to guarantee correctness of a concurrent simulation [3]-but this is often awkward, because model-checking languages are not very expressive, and intractably slow for even modest-sized systems. A better approach is to use a structural design rule such as I/O-PAR [4], which describes how to construct components of a parallel system that, when used to construct a complete system, will guarantee that the system as a whole is free from deadlock and livelock problems.…”

Relaxing B Sharing Restrictions within CSP||B

“…The reader interested in theoretical results is referred to [11,12] and the abundant CSP B literature referenced therein; for case studies, see for example [13,14].…”