2014
DOI: 10.1007/978-3-319-07692-8_3
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A Legendre Approximation for Solving a Fuzzy Fractional Drug Transduction Model into the Bloodstream

Abstract: Abstract. While an increasing number of fractional order integrals and differential equations applications have been reported in the physics, signal processing, engineering and bioengineering literatures, little attention has been paid to this class of models in the pharmacokineticspharmacodynamic (PKPD) literature. In this research, we are confined with the application of Legendre operational matrix for solving fuzzy fractional differential equation arising in the drug delivery model into the bloodstream. The… Show more

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Cited by 12 publications
(3 citation statements)
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“…To this end, they exploited generalized H-differentiability and derived the solutions based on this concept. Ahmadian et al [22] were confined with the application of Legendre operational matrix for solving FFDEs arising in the drug delivery model into the bloodstream. The main motivation of this research is to recommend a suitable way to approximate fuzzy fractional pharmacokinetics-pharmacodynamic models using a shifted Legendre tau approach.…”
Section: Introductionmentioning
confidence: 99%
“…To this end, they exploited generalized H-differentiability and derived the solutions based on this concept. Ahmadian et al [22] were confined with the application of Legendre operational matrix for solving FFDEs arising in the drug delivery model into the bloodstream. The main motivation of this research is to recommend a suitable way to approximate fuzzy fractional pharmacokinetics-pharmacodynamic models using a shifted Legendre tau approach.…”
Section: Introductionmentioning
confidence: 99%
“…The new well-known numerical scheme, like the non-standard finite difference scheme In the end, we could extend this idea to all types of nonlinear and complex models. In the future, we could develop our analysis into fuzzy epidemic models and many other types of modeling as given in [27][28][29][30][31].…”
Section: Discussionmentioning
confidence: 99%
“…Ahmadian et al 18 proposed a Jacobi tau method to simulate the concentration of drug in blood for the fuzzy fractional pharmacokinetics. And then in order to solve the fuzzy fractional differential equation arising in the drug delivery model, Ahmadian et al 19 also gave a numerical method based on Legendre operational matrix. Dokoumetzidis et al applied the numerical inverse Laplace transform (NILT) method to solve the system they proposed, 14 but the direct numerical simulation of the two‐compartmental fractional model was not considered in their studies.…”
Section: Introductionmentioning
confidence: 99%