A Lichen Substance as an Antiproliferative Compound against HL-60 Human Leukemia Cells: 16-<i>O</i>-Acetyl-leucotylic Acid Isolated from<i>Myelochroa aurulenta</i>

Tokiwano, Tetsuo; Satoh, Hajime; Obara, Tomohisa; Harada, Hiroshi; Yoshizawa, Yuko; Yamamoto, Yoshikazu

doi:10.1271/bbb.90419

Cited by 17 publications

(2 citation statements)

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“…(Hauck et al 2009). Some lichen compounds were shown to exhibit antibacterial (Motohashi et al 2010;Paudel et al 2010), cytostatic (Bogo et al 2010;Millot et al 2009;Tokiwano et al 2009), and antiviral activities (Esimone et al 2009). Indeed, major improvements in spectroscopy and systems biology have also stimulated renewed interest in the structural, metabolic and pharmaceutical analysis of lichen compounds.…”

Section: Lichen Chemistrymentioning

confidence: 99%

Advanced methods for the study of the chemistry and the metabolism of lichens

2011

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Lichens are compound entities of a fungal partner (''mycobiont'') and one or more photosynthetically active algae or cyanobacteria (''photobionts''). The organisms live in an intimate, symbiotic association which has been classified as a mutualistic or controlled parasitic relationship. Several metabolites from lichens display unique structures with unknown functions, and only a few model species have been analysed comprehensively. The complex metabolic interplay between the organisms in lichens is also incompletely understood. Earlier experiments with 14 C-labelled precursors indicated that the photobionts produce from CO 2 glucose or sugar alcohols (e.g. ribitol and arabitol) which are then transferred to the mycobionts. In the fungi, these compounds are believed to be converted into mannitol serving as the carbon and energy source in the downstream metabolic processes. Recent methodological developments in spectroscopy and ''systems biology'' now enable a concise analysis of the metabolite profiles, networks and fluxes by non-targeted quantitative approaches. In this review, we summarize the current knowledge about lichen metabolism and report on the potential of the advanced methods to reinvestigate lichen chemistry and metabolism on a quantitative basis.

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Section: Lichen Chemistrymentioning

confidence: 99%

Advanced methods for the study of the chemistry and the metabolism of lichens

2011

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“…Both caspase-dependent and caspase-independent pathways were responsible for apoptosis in PC-3 cells. It should also be noted that 16-O-acetyl-leucotylic acid, a new triterpenic acid, exhibited potent antiproliferative activity against HL-60 with an EC50 value of 21 μM, while the leucotylic acid, derivative of 16-O-acetyl-leucotylic acid, has a higher EC50 value (72 μM) (Tokiwano et al 2009). …”

Section: Others: Some Specific Class Of Compoundsmentioning

confidence: 99%