A light and electron microscopical study of glomerular lipoidosis in beagle dogs

Zayed, I.; Gopinath, C.; Hornstra, H.W.; Spit, B.J.; Heijden, C.A. van der

doi:10.1016/0021-9975(76)90060-8

Cited by 16 publications

(5 citation statements)

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“…Glomerular lipidosis in dogs has most often been reported as a sporadic, incidental glomerular change in kidneys that otherwise lack significant pathology. 47,55 This association between glomerular lipidosis and FSGS may change as larger numbers of cases are eventually considered, but its occurrence in a small number of FSGS cases in this study suggests that glomerular lipidosis may have pathologic significance. Future studies of the lesion of glomerular lipidosis in dogs are warranted.…”

Section: Discussionmentioning

confidence: 77%

World Small Animal Veterinary Association Renal Pathology Initiative

et al. 2015

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Evaluation of canine renal biopsy tissue has generally relied on light microscopic (LM) evaluation of hematoxylin and eosin-stained sections ranging in thickness from 3 to 5 µm. Advanced modalities, such as transmission electron microscopy (TEM) and immunofluorescence (IF), have been used sporadically or retrospectively. Diagnostic algorithms of glomerular diseases have been extrapolated from the World Health Organization classification scheme for human glomerular disease. With the recent establishment of 2 veterinary nephropathology services that evaluate 3-µm sections with a panel of histochemical stains and routinely perform TEM and IF, a standardized objective species-specific approach for the diagnosis of canine glomerular disease was needed. Eight veterinary pathologists evaluated 114 parameters (lesions) in renal biopsy specimens from 89 dogs. Hierarchical cluster analysis of the data revealed 2 large categories of glomerular disease based on the presence or absence of immune complex deposition: The immune complex-mediated glomerulonephritis (ICGN) category included cases with histologic lesions of membranoproliferative or membranous patterns. The second category included control dogs and dogs with non-ICGN (glomerular amyloidosis or focal segmental glomerulosclerosis). Cluster analysis performed on only the LM parameters led to misdiagnosis of 22 of the 89 cases-that is, ICGN cases moved to the non-ICGN branch of the dendrogram or vice versa, thereby emphasizing the importance of advanced diagnostic modalities in the evaluation of canine glomerular disease. Salient LM, TEM, and IF features for each pattern of disease were identified, and a preliminary investigation of related clinicopathologic data was performed.

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Section: Discussionmentioning

confidence: 77%

World Small Animal Veterinary Association Renal Pathology Initiative

et al. 2015

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“…Although its pathogenesis is obscure, the lesions are distinct. Light and ultramicroscopic features of spontaneous canine glomerular lipidosis also have been described [89]. The affected glomeruli showed eosinophilic foamy transformation of part of a glomerulus in a segmental fashion.…”

Section: Clomerulonephritis In Dogsmentioning

confidence: 88%

Comparative Pathology of Glomerulonephritis in Animals

Slauson

Lewis

1979

Vet Pathol

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Abstract. Glomerulonephritis constitutes an important category of renal diseases in animals and has been recognized with increasing frequency in the last decade. We report here the comparative morphologic aspects of glomerulonephritis as a naturally occurring disease of animals. We briefly review the immunopathogenesis of glomerulonephritis. The morphology of renal lesions occurring in glomerulonephritis in dogs, cats, cattle, sheep, horses and swine has been reviewed with emphasis on the range and specificity of various glomerular lesions and on the comparison of lesions between various species. A distinction was made between glornerulonephritis as a primary disease entity and glomerulonephritis associated with other disease processes. Primary idiopathic glomerulonephritis occurred in all species but was most commonly recognized as a clinically important disease in dogs and cats. Glomerulonephritis also occurred in association with other diseases such as equine infectious anemia, chronic hog cholera, canine pyometra, dirofilariasis, feline leukemia virus infection and canine systemic lupus erythematosus.Glomerulonephritis is responsible for substantial morbidity and mortality in many species of animals. Although the cause is basically unknown, it is a disease generally thought to result from the interaction of immunologic and inflammatory reactants at a fixed tissue site (the glomeruli) with subsequent loss of structural and functional integrity of the injured tissues. It is not the purpose of this paper to detail the pathogenesis of glomerulonephritis. For a better understanding of the disease as it occurs in animals, however, it will be useful to review briefly what is known about the pathways potentially leading to glomerular injury [25, 61, 71, 73, 77, 82, 831. Two major immunologic mechanisms of glomerular injury have been identified. In one, antibodies react with antigens in the glomerular basement membrane. In the other, antibodies react with nonglomerular antigens in the circulation to form immune complexes that are deposited in the glomerulus. With conventional light microscopy, it is difficult to infer the pathogenetic mechanisms responsible for glomerulonephritis from the histologic lesion. Differentiating these two mechanisms usually requires fluorescence and electron microscopy. Glomerular lesions induced by soluble immune complexes have characteristic discrete, interrupted, focal deposits of host IgG and complement when examined by fluorescence microscopy. In contrast, the fluorescence staining pattern of glomeruli injured by anti-glomerular basement membrane antibody is uniform, smooth and linear. To further implicate anti-glo- 135

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“…It was determined to be a segmental change in mesangial cells of the glomerular tuft with aggregation of lipid-laden foam cells; this lesion did not appear to affect overlying podocytes. 22 Shortly thereafter, a study using rabbits fed high-cholesterol diets determined that glomerular foam cells were derived from migrant blood monocytes and mesangial cells but not from glomerular endothelium. 18 These foam cells could be observed in capillary lumina or within the mesangium, and the lipid was present as non–membrane-bound cytoplasmic droplets.…”

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confidence: 99%

Glomerular Lipidosis in Dogs

et al. 2017

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Glomerular lipidosis (GL) is characterized by dilated glomerular capillary loops containing lipid-laden cells (foam cells). Previously, GL was considered to be an incidental finding because affected dogs were typically not azotemic. However, the International Renal Interest Society staging system for canine chronic kidney disease has increased the awareness of other clinical parameters (eg, proteinuria and hypertension) that should be included in the assessment of renal function. As such, the aim of this study was to determine clinical abnormalities and concurrent renal lesions in dogs with GL. GL was identified in renal biopsies from 46 dogs evaluated by the International Veterinary Renal Pathology Service. GL was the sole diagnosis in 5 of 46 cases (11%), all of which were proteinuric. All 5 dogs had at least 1 additional clinicopathologic abnormality consistent with renal disease, including hypertension (4), azotemia (3), and/or hypoalbuminemia (2). The remaining 41 dogs had GL in combination with other glomerular lesions, the most common being focal segmental glomerulosclerosis (16, 35%), lesions consistent with juvenile nephropathy (8, 17%), and glomerular amyloidosis (5, 11%). Overall, dogs with severe GL were younger than were those with mild GL (P < .001). The percentage of glomeruli affected by GL differed by concurrent diagnoses (P = .034), with the highest percentage of affected glomeruli in dogs with GL alone or those with concurrent juvenile nephropathy. These findings suggest that GL should be a recognized histologic phenotype of glomerular injury associated with clinical renal dysfunction and/or juvenile nephropathies.

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A light and electron microscopical study of glomerular lipoidosis in beagle dogs

Cited by 16 publications

References 2 publications

World Small Animal Veterinary Association Renal Pathology Initiative

World Small Animal Veterinary Association Renal Pathology Initiative

Comparative Pathology of Glomerulonephritis in Animals

Glomerular Lipidosis in Dogs

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