A “light-up” fluorescent probe based on TEMPO-oxidation for the detection of ClO- and application in real samples

Small-molecule fluorescent probes based on covalent assembly strategy for chemoselective bioimaging

“…15A ). 88 During the reaction process, the primary alcohols in the probe CL1 are first oxidized to aldehydes by the active intermediates generated by ClO − and TEMPO. The new generated formyl groups are captured swiftly by the adjacent NH 2 groups initially, resulting in the spontaneous formation of phenanthridine compounds with strong fluorescence emission.…”

Reversible detection of hypochlorite using the deprotonation–protonation strategy: a search for new building blocks

“…4,5 Though the whole process is well regulated, however, a slight over production of hypochlorite may result in the accumulation of ClO À in living systems which eventually generates oxidative stress and hence can cause various neurodegenerative and cardiovascular diseases and cancer. [6][7][8] Over the last few years, a variety of reaction-based fluorescent probes involving irreversible changes around carbon-carbon, [9][10][11][12][13][14] carbon-nitrogen, 15,16 carbonsulphur, 17,18 and carbon-oxygen 19 bonds have been reported for the detection of hypochlorite (Table S1, ESI †). The reaction-based strategy is efficient but hypochlorite induced irreversible chemical changes are introduced in the probe as a result of which the probe is rendered useless after its first application.…”

An Acridine-Based Fluorescent Sensor for Monitoring ClO− in Water Samples and Zebrafish

“…Interest in quantification of reactive oxygen species (ROS) has grown owing to the indispensable role played by ROS in pathological and physiological processes [ 1 , 2 , 3 , 4 , 5 ]. For instance, recent research revealed that cancer cells steadily produce high concentrations of intracellular ROS, owing to carcinogenic deformation [ 6 , 7 , 8 ].…”