The highly selective and sensitive fluorescence "light-up" probe, 5′-(dimethylamino)-2′-formyl-N-hydroxy-[1,1′-biphenyl]-2-carboxamide(PTS), has been fabricated for the nerve-agent mimic diethyl chlorophosphate (DCP). The probe is designed by combining two novel strategies of "covalent assembly" and Lossen rearrangement. Formation of a phosphoryl intermediate from DCP and a hydroxamic acid group in PTS yields an isocyanate that quickly undergoes Lossen rearrangement to produce an aniline that condenses intramolecularly to a fluorescent phenanthridine system. PTS shows superior properties to probe DCP, such as rapid response (within 100 s), low detection limit (10.4 nM), specificity, and excellent linearity (R 2 = 0.9993) in the range from 2 to 16 μM. More importantly, its application of detecting DCP vapor has also been achieved with satisfying results.

A “Turn-On” fluorescent probe PBT for sensitive and selective detection of fluoride ions based on aggregation-induced emission.

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A turn-on fluorescent probe based on Si-rhodamine for sensitive and selective detection of phosgene in solution and in the gas phase.

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